ReviewPediatric research2018
Application of NPE in the assessment of a patent ductus arteriosus.
Review in Pediatric research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
78 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Early drug treatment in preterm patients with large patent ductus arteriosus at 28 weeks or less gestational age: systematic review and meta-analysis.Journal of perinatology : official journal of the California Perinatal Association · 2025Pooled it
- Conservative Management of Patent Ductus Arteriosus in Preterm Infants-A Systematic Review and Meta-Analyses Assessing Differences in Outcome Measures Between Randomized Controlled Trials and Cohort Studies.Frontiers in pediatrics · 2021Pooled it
- Spontaneous Closure of the Ductus Arteriosus in Preterm Infants: A Systematic Review.Frontiers in pediatrics · 2020Pooled it
- Melatonin effects on the left ventricular function in neonates with persistent pulmonary hypertension.European journal of pediatrics · 2026Trial
- Paracetamol or ibuprofen? A pilot study comparing rescue therapy for PDA in preterm infants within the first month.Frontiers in pediatrics · 2025Trial
- Adjusted versus Targeted Fortification in Extremely Low Birth Weight Preterm Infants: Fortin Study-A Randomized Clinical Trial.Nutrients · 2024Trial
- Trial of Selective Early Treatment of Patent Ductus Arteriosus with Ibuprofen.The New England journal of medicine · 2024Trial
- The use of milrinone in neonates with persistent pulmonary hypertension of the newborn - a randomised controlled trial pilot study (MINT 1).Journal of perinatology : official journal of the California Perinatal Association · 2023Trial
- Patent ductus arteriosus shunt elimination results in a reduction in adverse outcomes: a post hoc analysis of the PDA RCT cohort.Journal of perinatology : official journal of the California Perinatal Association · 2021Trial
- Point-of-Care Echocardiography in Pediatric and Neonatal Care.Indian journal of pediatrics · 2026Review
- Nutrition of the preterm infant with persistent ductus arteriosus: existing evidence and practical implications.Pediatric research · 2026Review
- Relationship between feeding milestones and comorbidities with the postnatal growth in preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Standard versus restricted fluid administration in preterm infants undergoing pharmacological treatment for haemodynamically significant patent ductus arteriosus.Pediatric research · 2026Article
- Cerebral and intestinal Doppler patterns according to patent ductus arteriosus shunt characteristics in preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Reliability of two-dimensional versus M-mode echocardiography for left atrium/aortic diameter ratio and fractional shortening in extremely preterm infants.Pediatric research · 2026Article
- [Selective interpretation of the "Guidelines and recommendations for targeted neonatal echocardiography and cardiac point-of-care ultrasound in the neonatal intensive care unit: an update from the American Society of Echocardiography"].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026Article
- Liver Regional Oxygen Saturation in Preterm Infants with Patent Ductus Arteriosus Status.Biomedicines · 2026Article
- Targeted Neonatal Echocardiography and Neonatal Hemodynamics in the Kingdom of Saudi Arabia:Saudi medical journal · 2026Article
- Association between hemodynamically significant patent ductus arteriosus and fluid intake in the first week of life in a cohort of very low birth weight preterm infants: the COOL study.European journal of pediatrics · 2025Article
- Association of patent ductus arteriosus duration with bronchopulmonary dysplasia and mortality: a cohort study.Pediatric research · 2025Article
18 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
In many preterm infants, the ductus arteriosus remains patent beyond the first few days of life. This prolonged patency is associated with numerous adverse outcomes, but the extent to which these adverse outcomes are attributable to the hemodynamic consequences of ductal patency, if at all, has not been established. Different treatment strategies have failed to improve short-term outcomes, with a paucity of data on the correct diagnostic and pathophysiological assessment of the patent ductus arteriosus (PDA) in association with long-term outcomes. Echocardiography is the selected method of choice for detecting a PDA, assessing the impact on the preterm circulation and monitoring treatment response. PDA in a preterm infant can result in pulmonary overcirculation and systemic hypoperfusion, Therefore, echocardiographic assessment should include evaluation of PDA characteristics, indices of pulmonary overcirculation with left heart loading conditions, and indices of systemic hypoperfusion. In this review, we provide an evidence-based overview of the current and emerging ultrasound measurements available to identify and monitor a PDA in the preterm infant. We offer indications and limitations for using Neonatologist Performed Echocardiography to optimize the management of a neonate with a PDA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.