mtDNA synthesis ignites the inflammasome.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

8 citing papers in PubMed.

1. Bidirectional Regulation of NLRP3 Inflammasome and Mitochondrial Quality Control in Sepsis: Mechanisms and Therapeutic Implications.Mediators of inflammation · 2026
   Review
2. Mitophagy in relation to chronic inflammation/ROS in aging.Molecular and cellular biochemistry · 2025
   Review
3. The importance of integrated therapies on cancer: Silibinin, an old and new molecule.Oncotarget · 2024
   Review
4. Review: Protective Immunity and Immunopathology of Ehrlichiosis.Zoonoses (Shannon, Ireland) · 2022
   Article
5. Immune system cells from COVID-19 patients display compromised mitochondrial-nuclear expression co-regulation and rewiring toward glycolysis.iScience · 2021
   Article
6. Human Autoinflammatory Diseases Mediated by NLRP3-, Pyrin-, NLRP1-, and NLRC4-Inflammasome Dysregulation Updates on Diagnosis, Treatment, and the Respective Roles of IL-1 and IL-18.Frontiers in immunology · 2020
   Review
7. Silibinin inhibits migration and invasion of breast cancer MDA-MB-231 cells through induction of mitochondrial fusion.Molecular and cellular biochemistry · 2020
   Article
8. Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors.Cell death & disease · 2019
   Review

Corrections and comments

• Comment on
  New mitochondrial DNA synthesis enables NLRP3 inflammasome activation.2018

Authors and funding

1 author.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

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