ArticleScientific reports2018
Deep brain optical coherence tomography angiography in mice: in vivo, noninvasive imaging of hippocampal formation.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24 citing papers in PubMed, 39 citations in OpenAlex.
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- Simultaneous three-photon and optical coherence microscopy deep within an intact mouse brain.Npj imaging · 2026Article
- Optical coherence tomography angiography reveals structural and hemodynamic remodeling of cerebral penetrating vessels owing to aging.Biomedical optics express · 2026Article
- Noninvasive optical monitoring of cerebral hemodynamics in a preclinical model of neonatal intraventricular hemorrhage.Frontiers in pediatrics · 2025Article
- Photoacoustic and fluorescence dual-modality imaging of cerebral biomarkers in Alzheimer's disease rodent model.Journal of biomedical optics · 2024Article
- Full-field amplitude speckle decorrelation angiography.Biomedical optics express · 2024Article
- Delineation of three-dimensional tumor margins based on normalized absolute difference mapping via volumetric optical coherence tomography.Scientific reports · 2024Article
- Quantum optical tomography based on time-resolved and mode-selective single-photon detection by femtosecond up-conversion.Scientific reports · 2023Article
- Review
- Deep Imaging to Dissect Microvascular Contributions to White Matter Degeneration in Rodent Models of Dementia.Stroke · 2023Review
- Non-destructive characterization of adult zebrafish models using Jones matrix optical coherence tomography.Biomedical optics express · 2022Article
- A versatile toolbox for studying cortical physiology in primates.Cell reports methods · 2022Article
- 1700 nm broadband laser source enables deep brain optical biopsy.Light, science & applications · 2021Article
- Closed-loop wavefront sensing and correction in the mouse brain with computed optical coherence microscopy.Biomedical optics express · 2021Article
- 1700 nm optical coherence microscopy enables minimally invasive, label-free, in vivo optical biopsy deep in the mouse brain.Light, science & applications · 2021Article
- Location Matters: Navigating Regional Heterogeneity of the Neurovascular Unit.Frontiers in cellular neuroscience · 2021Review
- Water wavenumber calibration for visible light optical coherence tomography.Journal of biomedical optics · 2020Article
- Longitudinal in-vivo OCM imaging of glioblastoma development in the mouse brain.Biomedical optics express · 2020Article
- Signal-to-background ratio and lateral resolution in deep tissue imaging by optical coherence microscopy in the 1700 nm spectral band.Scientific reports · 2019Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The hippocampus is associated with memory and navigation, and the rodent hippocampus provides a useful model system for studying neurophysiology such as neural plasticity. Vascular changes at this site are closely related to brain diseases, such as Alzheimer's disease, dementia, and epilepsy. Vascular imaging around the hippocampus in mice may help to further elucidate the mechanisms underlying these diseases. Optical coherence tomography angiography (OCTA) is an emerging technology that can provide label-free blood flow information. As the hippocampus is a deep structure in the mouse brain, direct in vivo visualisation of the vascular network using OCTA and other microscopic imaging modalities has been challenging. Imaging of blood vessels in the hippocampus has been performed using multiphoton microscopy; however, labelling with fluorescence probes is necessary when using this technique. Here, we report the use of label-free and noninvasive microvascular imaging in the hippocampal formation of mice using a 1.7-μm swept-source OCT system. The imaging results demonstrate that the proposed system can visualise blood flow at different locations of the hippocampus corresponding with deep brain areas.
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