ArticleThe American journal of gastroenterology2018
Enteric Infections Are Common in Patients with Flares of Inflammatory Bowel Disease.
Article in The American journal of gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
60 citing papers in PubMed, 1 synthesis or guideline pooled it, 98 citations in OpenAlex.
- Systematic review: gastrointestinal infection and incident inflammatory bowel disease.Alimentary pharmacology & therapeutics · 2020Pooled it
- Neglected kingdoms: the gut virome, mycobiome and their role in inflammatory bowel disease.Gut microbes · 2026Review
- Deciphering the Implications ofPathogens (Basel, Switzerland) · 2026Review
- Bacterial Gastrointestinal Infections in Pediatric Inflammatory Bowel Disease (PIBD)-A Single-Center Experience of Epidemiology, Management, and Outcome.Diagnostics (Basel, Switzerland) · 2026Article
- Corticosteroid Initiation Before Antimicrobials Does Not Increase the Risk of Adverse Outcomes Among Individuals Hospitalized With an IBD Flare and Enteric Infection.Journal of clinical gastroenterology · 2026Article
- The Knowledge, Attitude, and Perception (KAP) of Healthcare Professionals in Pediatric Settings Toward Oral Manifestations of Inflammatory Bowel Disease (IBD): A Survey-Based Cross-Sectional Study.Journal of clinical medicine · 2026Article
- Stool multiplex PCR assay versus conventional stool tests for detecting gastrointestinal infection as a cause for flare of inflammatory bowel disease.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026Article
- The role of gastrointestinal PCR in inflammatory bowel disease flares: A double-edged sword or a diagnostic breakthrough?Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026Review
- PCR-based stool testing for enteric infections in flares of inflammatory bowel disease: Is more data worth the cost?Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026Article
- Symptomatic Patients With Inflammatory Bowel Disease Do Not Always Require Treatment With Corticosteroids.Gastro hep advances · 2026Article
- Integrating multi-omics data to reveal the host-microbiota interactome in inflammatory bowel disease.Gut microbes · 2025Review
- Review
- Comparative Effectiveness of Ustekinumab and Vedolizumab as Maintenance Therapy After Tacrolimus-Induced Improvement in Patients with Acute Severe Ulcerative Colitis: A Retrospective Cohort Study.Journal of clinical medicine · 2025Article
- Article
- Applying Biomarkers in Treat-to-target Approach for IBD.Current gastroenterology reports · 2025Review
- Gut virome and its implications in the pathogenesis and therapeutics of inflammatory bowel disease.BMC medicine · 2025Review
- Gastrointestinal bacterial infections precede disease activation and treatment intensification in patients with inflammatory bowel disease.Therapeutic advances in gastroenterology · 2025Article
- Enteric Infection at Flare of Inflammatory Bowel Disease Impacts Outcomes at 2 Years.Inflammatory bowel diseases · 2024Article
- The effects of stress on gut virome: Implications on infectious disease and systemic disorders.MicrobiologyOpen · 2024Review
- Prevalence of Enteric Infections in Patients on Immune Checkpoint Inhibitors and Impact on Management and Outcomes.The oncologist · 2024Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesFew studies have examined the role of non-Clostridium difficile enteric infections in flares of inflammatory bowel disease (IBD). Our objective was to investigate enteric infection detected by multiplex PCR stool testing in patients with IBD.
methodsWe performed a cross-sectional analysis of 9403 patients who underwent 13,231 stool tests with a gastrointestinal pathogen PCR panel during a diarrheal illness from March 2015 to May 2017. Our primary outcome was the presence of an infection. Secondary outcomes included endoscopic and histologic predictors of infection, and IBD outcomes following testing.
resultsA total of 277 patients with Crohn's disease (CD), 300 patients with ulcerative colitis (UC), and 8826 patients without IBD underwent 454, 503, and 12,275 tests, respectively. Compared to patients without IBD, patients with IBD were less likely to test positive (CD 18.1%, UC 16.1%, no IBD 26.6%, p < 0.001). Compared to patients without IBD, CD had a higher prevalence of norovirus (p = 0.05) and Campylobacter (p = 0.043), whereas UC had a lower prevalence of norovirus (p = 0.001) and a higher prevalence of Campylobacter (p = 0.013), Plesiomonas (p = 0.049), and Escherichia coli species (p < 0.001). Of 77 patients who underwent endoscopy, there were no major endoscopic or histologic predictors of a positive test. Patients who tested negative were more likely to have IBD therapy escalated (p = 0.004). Enteric infection did not impact IBD outcomes following testing (log-rank 0.224).
conclusionsNon-Clostridium difficile enteric infections were identified in 17% of symptomatic patients with IBD. Endoscopic and histologic findings may not differentiate flare from infection. Norovirus and E.coli may play an important role in flare of IBD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.