Evidence map›Paper›PMID 30072768›Full record

ArticleInternational journal of impotence research2019

Pioglitazone's beneficial effects on erectile function preservation after cavernosal nerve injury in the rat are negated by inhibition of the insulin-like growth factor-1 receptor: a preclinical study.

Daniel J Heidenberg, Nora M Haney, Bashir M Rezk, Sudha Talwar, Samuel C Okpechi, Sudesh K Srivastav, Matthew Honda, Bryant Song, Kevin Swan, Salah Awadallah and 7 more

Abstract read
PubMed Publisher
In one paragraph

Article in International journal of impotence research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Effects of Anti-Diabetic Drugs on Erectile Dysfunction: A Systematic Review and Meta-Analysis.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025
    Review
  4. Review
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 1 country.

Daniel J HeidenbergDepartment of Urology, Tulane University School of Medicine, New Orleans, LA, USA.
Nora M HaneyDepartment of Urology, Tulane University School of Medicine, New Orleans, LA, USA.
Bashir M RezkDepartment of Urology, Tulane University School of Medicine, New Orleans, LA, USA.
Sudha TalwarDepartment of Urology, Tulane University School of Medicine, New Orleans, LA, USA.
Samuel C OkpechiDepartment of Natural Sciences, Biology Unit, Southern University at New Orleans, New Orleans, LA, USA.
Sudesh K SrivastavDepartment of Urology, Tulane University School of Medicine, New Orleans, LA, USA.
Matthew HondaDepartment of Urology, Tulane University School of Medicine, New Orleans, LA, USA.
Bryant SongLouisiana State University Health Sciences Center, New Orleans, LA, USA.
Kevin SwanLouisiana State University Health Sciences Center, New Orleans, LA, USA.
Salah AwadallahDepartment of Urology, Tulane University School of Medicine, New Orleans, LA, USA.
James AnaissieDepartment of Urology, Tulane University School of Medicine, New Orleans, LA, USA.
Taylor PeakDepartment of Urology, Tulane University School of Medicine, New Orleans, LA, USA.
Kenneth J DeLayDepartment of Urology, Tulane University School of Medicine, New Orleans, LA, USA.
Phillip J KadowitzDepartment of Urology, Tulane University School of Medicine, New Orleans, LA, USA.
Suresh C SikkaDepartment of Urology, Tulane University School of Medicine, New Orleans, LA, USA.
Asim B Abdel MageedDepartment of Urology, Tulane University School of Medicine, New Orleans, LA, USA.
Wayne J G HellstromDepartment of Urology, Tulane University School of Medicine, New Orleans, LA, USA. whellst@tulane.edu.
Tulane University · USLouisiana State University Health Sciences Center New Orleans · USSouthern University at New Orleans · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To determine if the insulin-like growth factor-1 (IGF-1) pathway is involved in the improvement in erectile function recovery in rats after nerve crush injury treated with pioglitazone (Pio). Sprague-Dawley rats were divided into four groups. The first group received sham operation (n = 5). The second group underwent bilateral cavernous nerve injury (BCNI, n  = 7). The third group received BCNI and Pio treatment (BCNI  +  Pio, n = 7), whereas the fourth group underwent BCNI with Pio treatment and IGF-1 inhibition (BCNI  +  Pio  +  JB-1, n = 7). The IGF-1 receptor (IGF-1R) was inhibited by JB-1, a small molecular antagonist of the receptor. After 14 days of treatment, erectile function was measured via intracorporal pressure normalized to mean arterial pressure (ICP/MAP) and the major pelvic ganglion and cavernous nerve harvested for western blot and immunohistochemistry (IHC) of phosphorylated-IGF-1Rβ (p-IGF-1Rβ), phosphorylated-ERK1/2 (p-ERK1/2), and neuronal NOS (nNOS). BCNI  +  Pio animals exhibited improvements in ICP/MAP, similar to Sham animals, and BCNI  +  Pio  +  JB-1 rats demonstrated a reduced ICP/MAP similar to BCNI-only rats at all measured voltages. Western blot results showed upregulation of p-IGF-1Rβ was observed in the BCNI  +  Pio group. Low levels of p-ERK1/2 were seen in the JB-1-treated animals. The immunoblot results were supported by IHC findings. Intense IHC staining of nNOS was detected in the BCNI  +  Pio group. The group treated with JB-1 showed minimal protein expression of p-ERK1/2, nNOS, and p-IGF-1Rβ. Pio improves erectile function in rats undergoing BCNI via an IGF-1-mediated pathway.

Indexed as

AnimalsErectile DysfunctionMaleNerve CrushNitric Oxide Synthase Type IPenile ErectionPeripheral Nerve InjuriesPhosphorylationPioglitazoneRatsRats, Sprague-DawleyReceptor, IGF Type 1Signal TransductionUp-RegulationNitric Oxide Synthase Type IPioglitazoneReceptor, IGF Type 1

Identifiers

PMID30072768
OpenAlexW2886843994

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.