Evidence map›Paper›PMID 30072741›Full record

SynthesisGenetics in medicine : official journal of the American College of Medical Genetics2021

Ethical, social, and cultural issues related to clinical genetic testing and counseling in low- and middle-income countries: a systematic review.

Adrina Zhong, Benedict Darren, Bethina Loiseau, Li Qun Betty He, Trillium Chang, Jessica Hill, Helen Dimaras

Open access · bronzeAbstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Genetics in medicine : official journal of the American College of Medical Genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 1 synthesis or guideline pooled it, 120 citations in OpenAlex.

  1. Prevalence and Incidence of Hereditary Angioedema: A Systematic Literature Review.International archives of allergy and immunology · 2026
    Pooled it
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8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Adrina ZhongDivision of Social and Behavioural Health Sciences, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
Benedict DarrenHuman Biology Program, Faculty of Arts & Science, University of Toronto, Toronto, ON, Canada.
Bethina LoiseauHuman Biology Program, Faculty of Arts & Science, University of Toronto, Toronto, ON, Canada.
Li Qun Betty HeHuman Biology Program, Faculty of Arts & Science, University of Toronto, Toronto, ON, Canada.
Trillium ChangHuman Biology Program, Faculty of Arts & Science, University of Toronto, Toronto, ON, Canada.
Jessica HillDepartment of Molecular Genetics, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Helen DimarasDivision of Clinical Public Health, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada. helen.dimaras@utoronto.ca.
University of Toronto · CAHospital for Sick Children · CAMcMaster University · CAPublic Health Ontario · CAUniversity of British Columbia · CA

Funding

CIHR
6 · The paper itself

Abstract

purposeWe performed a systematic review of the ethical, social, and cultural issues associated with delivery of genetic services in low- and middle-income countries (LMICs).

methodsWe searched 11 databases for studies addressing ethical, social, and/or cultural issues associated with clinical genetic testing and/or counselling performed in LMICs. Narrative synthesis was employed to analyze findings, and resultant themes were mapped onto the social ecological model (PROSPERO #CRD42016042894).

resultsAfter reviewing 13,308 articles, 192 met inclusion criteria. Nine themes emerged: (1) genetic counseling has a tendency of being directive, (2) genetic services have psychosocial consequences that require improved support, (3) medical genetics training is inadequate, (4) genetic services are difficult to access, (5) social determinants affect uptake and understanding of genetic services, (6) social stigma is often associated with genetic disease, (7) family values are at risk of disruption by genetic services, (8) religious principles pose barriers to acceptability and utilization of genetic services, and (9) cultural beliefs and practices influence uptake of information and understanding of genetic disease.

conclusionWe identified a number of complex and interrelated ethical, cultural, and social issues with implications implications for further development of genetic services in LMICs.

Indexed as

CounselingDeveloping CountriesGenetic TestingHumansPovertyGenetic counselingGeneticsGenetic testingGlobal healthLow- and middle-income countries

Identifiers

PMID30072741
OpenAlexW2885648482

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.