Observational studyHypertension research : official journal of the Japanese Society of Hypertension2018
High central blood pressure is associated with incident cardiovascular events in treated hypertensives: the ABC-J II Study.
Observational study in Hypertension research : official journal of the Japanese Society of Hypertension, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Association of cardiovascular events with central systolic blood pressure: A systemic review and meta-analysis.Journal of clinical hypertension (Greenwich, Conn.) · 2024Pooled it
- The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2019).Hypertension research : official journal of the Japanese Society of Hypertension · 2019Guideline
- Arterial Stiffness, Central Blood Pressure, and the Risk of Incident Stroke in Hypertensive Adults.European journal of neurology · 2025Article
- Independent and joint effect of central and brachial SBP on incident stroke in hypertensive adults.Journal of hypertension · 2025Article
- Article
- Positive association between triglyceride glucose index and central systolic blood pressure among hypertensive adults.Journal of geriatric cardiology : JGC · 2022Article
- Twenty-Four-Hour Central (Aortic) Systolic Blood Pressure: Reference Values and Dipping Patterns in Untreated Individuals.Hypertension (Dallas, Tex. : 1979) · 2022Article
- Prediction of Cardiovascular Events by Type I Central Systolic Blood Pressure: A Prospective Study.Hypertension (Dallas, Tex. : 1979) · 2021Article
- Central blood pressure predicts the development of hypertension in the general population.Hypertension research : official journal of the Japanese Society of Hypertension · 2020Observational
- Impact of hypertension on short- and long-term survival of patients who underwent emergency surgery for type A acute aortic dissection.Journal of thoracic disease · 2020Article
- Deterioration of sexual function is associated with central hemodynamics in adult Japanese men.Hypertension research : official journal of the Japanese Society of Hypertension · 2020Article
- Gathering evidence on the prognostic role of central blood pressure in hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2018Article
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Authors and funding
21 authors.
Funding
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Abstract
It is not established whether central blood pressure (BP) evaluated by a radial pulse wave analysis is useful to predict cardiovascular prognoses. We tested the hypothesis that central BP predicts future cardiovascular events in treated hypertensive subjects. We conducted a multicenter, observational cohort study of 3566 hypertensives being treated with antihypertensive medications at 27 institutions in Japan. We performed the radial pulse wave analyses using applanation tonometry in all subjects. The primary outcome was the incidence of any of the following: stroke, myocardial infarction (MI), sudden cardiac death, and acute aortic dissection. The mean age of the subjects was 66.0 ± 10.9 years, and 50.6% were male. The mean brachial SBP and central SBP were 138 ± 18 mm Hg and 128 ± 19 mm Hg, respectively. When the central SBP was divided into quintiles, the number of events was least in the 2nd quintile, and we set it as the reference. In the Cox regression analysis adjusting for age, sex, body mass index, creatinine, diabetes, use of β-blocker, and history of MI/stroke, the patients in the 3rd (hazard ratio (HR) 3.55, 95% confidence interval 1.29-9.78, p = 0.014), 4th (HR 4.12, 95% CI 1.53-11.10, p = 0.005), and 5th quintiles (HR 2.87, 95% CI 1.01-8.18, p = 0.048) had a significantly higher incidence of cardiovascular events compared to the 2nd quintile. The results were essentially unchanged when brachial DBP was additionally adjusted. In conclusion, in treated hypertensives, high central SBP was associated with worse cardiovascular outcomes.
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