ArticleNature protocols2018
Pig lung transplant survival model.
Article in Nature protocols, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Preclinical Large AnimalCurrent cardiology reviews · 2023Pooled it
- Evaluation of the Effectiveness of a Novel Wireless Energy-Transmitting Implantable Diaphragm Pacemaker in Anesthetized Pigs.Bioengineering (Basel, Switzerland) · 2026Article
- Article
- Porcine xenotransplantation in the clinical era: converging advances and unresolved barriers on the path to clinical translation - a narrative review.Frontiers in immunology · 2026Review
- Transgluteal vs. Anterior and Posterior Approaches for Porcine Model of Irreparable Acetabular Labral Tear: A Comparative Study on Feasibility and Safety.BioMed research international · 2026Article
- Article
- Contributions of large and agricultural animal models to immunology.Journal of immunology (Baltimore, Md. : 1950) · 2025Review
- Ex vivo lung perfusion-to-lung transplant rat survival model with reproducible development of acute lung injury and graft rejection.JHLT open · 2025Article
- Activation of Nrf2 pathway by 4-Octyl itaconate enhances donor lung function in cold preservation settings.Respiratory research · 2025Article
- Surgical Protocol for Partial Heart Transplantation in Growing Piglets.World journal for pediatric & congenital heart surgery · 2024Article
- Article
- Penehyclidine hydrochloride alleviates lung ischemia-reperfusion injury by inhibiting pyroptosis.BMC pulmonary medicine · 2024Article
- Changes in the levels of free sialic acid during ex vivo lung perfusion do not correlate with pulmonary function. Experimental model.BMC pulmonary medicine · 2023Article
- The Importance of Animal Models in Biomedical Research: Current Insights and Applications.Animals : an open access journal from MDPI · 2023Review
- Article
- Differential early response of monocyte/macrophage subsets to intra-operative corticosteroid administration in lung transplantation.Frontiers in immunology · 2023Article
- Reduction of primary graft dysfunction using cytokine adsorption during organ preservation and after lung transplantation.Nature communications · 2022Article
- Right lung transplantation with a left-to-right inverted anastomosis in a rat model.JTCVS open · 2022Article
- The de novo assembly of a European wild boar genome revealed unique patterns of chromosomal structural variations and segmental duplications.Animal genetics · 2022Article
- Endothelin-Converting Enzyme 1 and Vascular Endothelial Growth Factor as Potential Biomarkers duringDisease markers · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although lung transplant is a life-saving therapy for some patients, primary graft dysfunction (PGD) is a leading cause of mortality and morbidity soon after a transplant. Ischemia reperfusion injury is known to be one of the most critical factors in PGD development. PGD is by definition an acute lung injury syndrome that occurs during the first 3 d following lung transplantation. To successfully translate laboratory discoveries to clinical practice, a reliable and practical large animal model is critical. This protocol describes a surgical technique for swine lung transplantation and postoperative management for a further 3 d post transplant. The protocol includes the background and rationale, required supplies, and a detailed description of the donor operation, transplant surgery, postoperative care, and sacrifice surgery. A pig lung transplant model is reliably produced in which the recipients survive for 3 d post transplant. This 3-d survival model can be used by lung transplant researchers to assess the development of PGD and to test therapeutic strategies targeting PGD. In total, the protocol requires 5 h for the surgeries, plus ~2 h in total for the postoperative care.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.