SynthesisTranslational psychiatry2018
Striatal dopaminergic alterations in Tourette's syndrome: a meta-analysis based on 16 PET and SPECT neuroimaging studies.
Synthesis in Translational psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Tourette syndrome.Nature reviews. Disease primers · 2026Review
- Comparative analysis of the cellular landscape in mammalian striatum.Nature communications · 2026Article
- Sex Differences in Histamine Regulation of Striatal Dopamine.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Advancing Obsessive-Compulsive Disorder Research: Insights from Transgenic Animal Models and Innovative Therapies.Brain sciences · 2025Review
- Abnormalities of iron homeostasis and the dopaminergic system in Tourette syndrome revealed by 7T MRI and PET.Brain communications · 2025Article
- Knockdown of themicroPublication biology · 2024Article
- Chronic stress promotes basal ganglia disinhibition by increasing the excitatory drive of direct-pathway neurons.Neurobiology of stress · 2023Article
- The inflammatory injury in the striatal microglia-dopaminergic-neuron crosstalk involved in Tourette syndrome development.Frontiers in immunology · 2023Article
- Developmental impact of glutamate transporter overexpression on dopaminergic neuron activity and stereotypic behavior.Molecular psychiatry · 2022Article
- Allopregnanolone: The missing link to explain the effects of stress on tic exacerbation?Journal of neuroendocrinology · 2022Review
- Dopamine-2 receptor antibody encephalitis presenting as pure tongue-biting in a tourette syndrome patient: a case report.BMC psychiatry · 2022Article
- Association of Prenatal Maternal Anemia with Tics and Tourette's Syndrome in Offspring.Journal of personalized medicine · 2021Article
- Article
- Time estimation in a case of Tourette's syndrome: Effect of antipsychotic medications.Neuropsychopharmacology reports · 2020Article
- Changing Visual Defects in a Patient with Gilles de la Tourette Syndrome.Neuro-ophthalmology (Aeolus Press) · 2020Article
- Refractory Gilles de la Tourette Syndrome-Many Pieces That Define the Puzzle.Frontiers in neurology · 2020Review
- A Review of the Current Treatment of Tourette Syndrome.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2020Review
- Tourette syndrome research highlights from 2018.F1000Research · 2019Review
- Merging the Pathophysiology and Pharmacotherapy of Tics.Tremor and other hyperkinetic movements (New York, N.Y.) · 2018Review
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite intense research, the underlying mechanisms and the etiology of Tourette's syndrome (TS) remain unknown. Data from molecular imaging studies targeting the dopamine system in Tourette patients are inconclusive. For a better understanding of the striatal dopamine function in adult dopamine-antagonist-free patients we performed a systematic review in August 2017 identifying 49 PET and SPECT studies on the topic of TS. A total of 8 studies appraised the dopamine transporter (DAT) with 111 Tourette patients and 93 healthy controls, and could be included in a meta-analytic approach. We found a significantly increased striatal DAT binding in Tourette patients (Hedges' g = 0.49; 95% CI: (0.01-0.98)), although this effect did not remain significant after correcting for age differences between cohorts. A second meta-analysis was performed for the striatal dopamine receptor including 8 studies with a total of 72 Tourette patients and 71 controls. This analysis revealed a nonsignificant trend toward lower dopamine 2/3 receptor binding in striatum of Tourette patients. Other analyses regarding study population characteristics in both the DAT and receptor meta-analysis did not show any meaningful results. Our results indicate that dopaminergic alterations in TS are likely and thereby this data would be in line with the current pathophysiological hypotheses of a dysfunction in the dopamine system, e.g., the hypothesis of tonic-phasic dysfunction. However, these analyses suffer from low effect sizes probably due to the heterogeneity of TS and highlight the need for further large-scaled neuroimaging studies.
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