Evidence map›Paper›PMID 30072692›Full record

ArticleNature communications2018

Cross-reactive Dengue virus-specific CD8

Jose Angel Regla-Nava, Annie Elong Ngono, Karla M Viramontes, Anh-Thy Huynh, Ying-Ting Wang, Anh-Viet T Nguyen, Rebecca Salgado, Anila Mamidi, Kenneth Kim, Michael S Diamond and 1 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed
14.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 102 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Human coronavirus OC43-elicited CD4Nature communications · 2024
    Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Jose Angel Regla-NavaDivision of Inflammation Biology, La Jolla Institute for Allergy & Immunology, 92037, La Jolla, CA, USA.
Annie Elong NgonoDivision of Inflammation Biology, La Jolla Institute for Allergy & Immunology, 92037, La Jolla, CA, USA.
Karla M ViramontesDivision of Inflammation Biology, La Jolla Institute for Allergy & Immunology, 92037, La Jolla, CA, USA.
Anh-Thy HuynhDivision of Inflammation Biology, La Jolla Institute for Allergy & Immunology, 92037, La Jolla, CA, USA.
Ying-Ting WangDivision of Inflammation Biology, La Jolla Institute for Allergy & Immunology, 92037, La Jolla, CA, USA.
Anh-Viet T NguyenDivision of Inflammation Biology, La Jolla Institute for Allergy & Immunology, 92037, La Jolla, CA, USA.
Rebecca SalgadoDivision of Inflammation Biology, La Jolla Institute for Allergy & Immunology, 92037, La Jolla, CA, USA.
Anila MamidiDivision of Inflammation Biology, La Jolla Institute for Allergy & Immunology, 92037, La Jolla, CA, USA.
Kenneth KimDivision of Inflammation Biology, La Jolla Institute for Allergy & Immunology, 92037, La Jolla, CA, USA.
Michael S DiamondDepartment of Medicine, Molecular Microbiology, Pathology, and Immunology, Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, 63110, St. Louis, MO, USA.
Sujan ShrestaDivision of Inflammation Biology, La Jolla Institute for Allergy & Immunology, 92037, La Jolla, CA, USA. sujan@lji.org.
La Jolla Institute for Immunology · USUniversity of California, San Diego · USWashington University in St. Louis · US

Funding

T Cell Responses Following DENV Natural Infections and Live-Attenuated Dengue Virus VaccinationP01AI106695 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI Aravinda M. DeSilva · 2015 to 2026
$34.1M
Antibody-based Protection against FlavivirsesR01AI073755 · NIAID · WASHINGTON UNIVERSITY · PI DIAMOND, MICHAEL S, FREMONT, DAVED H. · 2007 to 2022
$11.4M
Human neutralizing antibodies for Zika virusR01AI127828 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CROWE, JAMES E, DIAMOND, MICHAEL S · 2017 to 2021
$3.9M
IRF-3/5/7-Independent Antiviral ImmunityR01AI116813 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI SHRESTA, SUJAN · 2016 to 2019
$1.9M
Host-pathogen interactions in ZIKV infection leading to microcephalyR21NS100477 · NINDS · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI SHRESTA, SUJAN, STRONGIN, ALEX Y · 2016 to 2017
$544k
NIAID NIH HHS P01 AI106695NIAID NIH HHS R01 AI073755NIAID NIH HHS R01 AI116813NIAID NIH HHS R01 AI127828NINDS NIH HHS R21 NS100477
6 · The paper itself

Abstract

As Zika virus (ZIKV) emerges into Dengue virus (DENV)-endemic areas, cases of ZIKV infection in DENV-immune pregnant women may rise. Here we show that prior DENV immunity affects maternal and fetal ZIKV infection in pregnancy using sequential DENV and ZIKV infection models. Fetuses in ZIKV-infected DENV-immune dams were normal sized, whereas fetal demise occurred in non-immune dams. Moreover, reduced ZIKV RNA is present in the placenta and fetuses of ZIKV-infected DENV-immune dams. DENV cross-reactive CD8

Indexed as

AnimalsCD8-Positive T-LymphocytesCross ReactionsDeciduaDengue VirusEpitopesFemaleFetusMice, Inbred C57BLPhenotypePregnancySpecies SpecificitySpleenViral LoadZika VirusZika Virus InfectionEpitopes

Identifiers

PMID30072692
PMCPMC6072705
OpenAlexW2883322534

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.