Evidence map›Paper›PMID 30072672›Full record

ReviewMolecules (Basel, Switzerland)2018

Use of Cyclodextrins in Anticancer Photodynamic Therapy Treatment.

Amina Ben Mihoub, Ludivine Larue, Albert Moussaron, Zahraa Youssef, Ludovic Colombeau, Francis Baros, Céline Frochot, Régis Vanderesse, Samir Acherar

Open access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 55 citations in OpenAlex.

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  20. Introduction to "Advances in Photodynamic Therapy 2018".Molecules (Basel, Switzerland) · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Amina Ben MihoubLaboratoire de Chimie Phusique Macromoléculaire, Université de Lorraine, CNRS, LCPM, F-54000 Nancy, France. amina.ben-mihoub@univ-lorraine.fr.
Ludivine LarueLaboratoire de Chimie Phusique Macromoléculaire, Université de Lorraine, CNRS, LCPM, F-54000 Nancy, France. ludivine.larue@univ-lorraine.fr.
Albert MoussaronLaboratoire de Chimie Phusique Macromoléculaire, Université de Lorraine, CNRS, LCPM, F-54000 Nancy, France. albert.moussaron@univ-lorraine.fr.
Zahraa YoussefLaboratoire Réactions et Génie des Procédés, Université de Lorraine, CNRS, LRGP, F-54000 Nancy, France. zahraa.youssef@univ-lorraine.fr.
Ludovic ColombeauLaboratoire de Chimie Phusique Macromoléculaire, Université de Lorraine, CNRS, LCPM, F-54000 Nancy, France. ludovic.colombeau@univ-lorraine.fr.
Francis BarosLaboratoire Réactions et Génie des Procédés, Université de Lorraine, CNRS, LRGP, F-54000 Nancy, France. francis.baros@univ-lorraine.fr.
Céline FrochotLaboratoire Réactions et Génie des Procédés, Université de Lorraine, CNRS, LRGP, F-54000 Nancy, France. celine.frochot@univ-lorraine.fr.ORCID 0000-0002-7659-3864
Régis VanderesseLaboratoire de Chimie Phusique Macromoléculaire, Université de Lorraine, CNRS, LCPM, F-54000 Nancy, France. regis.vanderesse@univ-lorraine.fr.
Samir AcherarLaboratoire de Chimie Phusique Macromoléculaire, Université de Lorraine, CNRS, LCPM, F-54000 Nancy, France. samir.acherar@univ-lorraine.fr.
Centre National de la Recherche Scientifique · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Photodynamic therapy (PDT) is mainly used to destroy cancerous cells; it combines the action of three components: a photoactivatable molecule or photosensitizer (PS), the light of an appropriate wavelength, and naturally occurring molecular oxygen. After light excitation of the PS, the excited PS then reacts with molecular oxygen to produce reactive oxygen species (ROS), leading to cellular damage. One of the drawbacks of PSs is their lack of solubility in water and body tissue fluids, thereby causing low bioavailability, drug-delivery efficiency, therapeutic efficacy, and ROS production. To improve the water-solubility and/or drug delivery of PSs, using cyclodextrins (CDs) is an interesting strategy. This review describes the in vitro or/and in vivo use of natural and derived CDs to improve antitumoral PDT efficiency in aqueous media. To achieve these goals, three types of binding modes of PSs with CDs are developed: non-covalent CD⁻PS inclusion complexes, covalent CD⁻PS conjugates, and CD⁻PS nanoassemblies. This review is divided into three parts: (1) non-covalent CD-PS inclusion complexes, covalent CD⁻PS conjugates, and CD⁻PS nanoassemblies, (2) incorporating CD⁻PS systems into hybrid nanoparticles (NPs) using up-converting or other types of NPs, and (3) CDs with fullerenes as PSs.

Indexed as

PhotochemotherapyAntineoplastic AgentsCyclodextrinsFullerenesHumansLightNanoparticlesPhotosensitizing AgentsAntineoplastic AgentsCyclodextrinsFullerenesPhotosensitizing Agentscancerconjugatecylodextrinfullereneinclusion complexnanoassemblynanoparticlephotodynamic therapyphotosensitizerporphyrinoid

Identifiers

PMID30072672
PMCPMC6222782
OpenAlexW2885541675

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.