Evidence map›Paper›PMID 30072645›Full record

ArticleGenes2018

An Integrated Approach for Identifying Molecular Subtypes in Human Colon Cancer Using Gene Expression Data.

Wen-Hui Wang, Ting-Yan Xie, Guang-Lei Xie, Zhong-Lu Ren, Jin-Ming Li

Abstract read
In one paragraph

Article in Genes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Wen-Hui WangState Key Laboratory of Organ Failure Research, Division of Nephrology, Southern Medical University, Guangzhou 510515, China. thineeyes@163.com.ORCID 0000-0002-9623-0489
Ting-Yan XieState Key Laboratory of Organ Failure Research, Division of Nephrology, Southern Medical University, Guangzhou 510515, China. bobanne@163.com.
Guang-Lei XieState Key Laboratory of Organ Failure Research, Division of Nephrology, Southern Medical University, Guangzhou 510515, China. xgl343@smu.edu.cn.
Zhong-Lu RenCenter for Systems Medical Genetics, Department of Obstetrics & Gynecology Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. renzhonglu@smu.edu.cn.
Jin-Ming LiState Key Laboratory of Organ Failure Research, Division of Nephrology, Southern Medical University, Guangzhou 510515, China. jmli@smu.edu.cn.ORCID 0000-0002-8595-1061

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Identifying molecular subtypes of colorectal cancer (CRC) may allow for more rational, patient-specific treatment. Various studies have identified molecular subtypes for CRC using gene expression data, but they are inconsistent and further research is necessary. From a methodological point of view, a progressive approach is needed to identify molecular subtypes in human colon cancer using gene expression data. We propose an approach to identify the molecular subtypes of colon cancer that integrates denoising by the Bayesian robust principal component analysis (BRPCA) algorithm, hierarchical clustering by the directed bubble hierarchical tree (DBHT) algorithm, and feature gene selection by an improved differential evolution based feature selection method (DEFS

Indexed as

Bayesian robust principal componentcolon cancerfeature selectionhierarchical clusteringsubtypes of cancer

Identifiers

PMID30072645
PMCPMC6115727

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.