Evidence map›Paper›PMID 30072444›Full record

ArticleJournal of cell science2018

Cell injury triggers actin polymerization to initiate epithelial restitution.

Eitaro Aihara, Neisha M Medina-Candelaria, Hikaru Hanyu, Andrea L Matthis, Kristen A Engevik, Christine B Gurniak, Walter Witke, Jerrold R Turner, Tongli Zhang, Marshall H Montrose

Open access · bronzeAbstract read
In one paragraph

Article in Journal of cell science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
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  9. Review
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  14. Article
  15. Gastroduodenal Injury: Role of Protective Factors.Current gastroenterology reports · 2019
    Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Eitaro AiharaDepartment of Pharmacology and Systems Physiology, University of Cincinnati, Cincinnati, OH 45267, USA aiharaeo@uc.edu mhm@uc.edu.ORCID 0000-0003-1160-4929
Neisha M Medina-CandelariaDepartment of Pharmacology and Systems Physiology, University of Cincinnati, Cincinnati, OH 45267, USA.ORCID 0000-0002-7059-1905
Hikaru HanyuDepartment of Pharmacology and Systems Physiology, University of Cincinnati, Cincinnati, OH 45267, USA.
Andrea L MatthisDepartment of Pharmacology and Systems Physiology, University of Cincinnati, Cincinnati, OH 45267, USA.
Kristen A EngevikDepartment of Pharmacology and Systems Physiology, University of Cincinnati, Cincinnati, OH 45267, USA.
Christine B GurniakInstitute of Genetics, University of Bonn, Bonn, Germany.
Walter WitkeInstitute of Genetics, University of Bonn, Bonn, Germany.
Jerrold R TurnerDepartments of Pathology and Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Tongli ZhangDepartment of Pharmacology and Systems Physiology, University of Cincinnati, Cincinnati, OH 45267, USA.
Marshall H MontroseDepartment of Pharmacology and Systems Physiology, University of Cincinnati, Cincinnati, OH 45267, USA aiharaeo@uc.edu mhm@uc.edu.ORCID 0000-0002-1847-0276
University of Cincinnati · USUniversity of Bonn · DEBrigham and Women's Hospital · US

Funding

STRUCTURE-FUNCTION RELATIONSHIPS IN THE ALIMENTARY TRACTP30DK034854 · NIDDK · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI JONATHAN C KAGAN · 1986 to 2026
$32.4M
Stem Cell/Organoid and Genome Editing CoreP30DK078392 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI Alexander Miethke · 2007 to 2026
$24.4M
ZO-1-MEDIATED PROTEIN INTERACTIONS: REGULATORS AND INTEGRATORS OF DIVERSE EPITHELIAL FUNCTIONS IN HEALTH AND DISEASER01DK061931 · NIDDK · UNIVERSITY OF CHICAGO · PI JERROLD R. TURNER · 2001 to 2026
$15.0M
Therapeutic targeting of protein interactions to reverse MLCK1-mediated intestinal barrier loss and ameliorate disease.R01DK068271 · NIDDK · UNIVERSITY OF CHICAGO · PI JERROLD R. TURNER · 2005 to 2026
$11.3M
Mechanisms of essential calcium signaling during gastric epithelial wound healingR01DK102551 · NIDDK · UNIVERSITY OF CINCINNATI · PI MONTROSE, MARSHALL H · 2015 to 2018
$1.4M
NIDDK NIH HHS P30 DK034854NIDDK NIH HHS P30 DK078392NIDDK NIH HHS R01 DK061931NIDDK NIH HHS R01 DK068271NIDDK NIH HHS R01 DK102551
6 · The paper itself

Abstract

The role of the actin cytoskeleton in the sequence of physiological epithelial repair in the intact epithelium has yet to be elucidated. Here, we explore the role of actin in gastric repair

Indexed as

ActinsAnimalsCell MovementCells, CulturedEpithelial CellsFemaleGastric MucosaMaleMiceMice, TransgenicOrganoidsPolymerizationProtein MultimerizationRe-EpithelializationRegenerationStomachActinsActinCell migrationEpithelial cellGastric organoidRepair

Identifiers

PMID30072444
PMCPMC6127731
OpenAlexW2886259050

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.