Evidence map›Paper›PMID 30072373›Full record

ArticleThe Journal of general physiology2018

Rapid constriction of the selectivity filter underlies C-type inactivation in the KcsA potassium channel.

Jing Li, Jared Ostmeyer, Luis G Cuello, Eduardo Perozo, Benoît Roux

Abstract read
In one paragraph

Article in The Journal of general physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed.

  1. Gating crosstalk in potassium channels.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. Article
  4. A Historical Outline of Fluorescence Spectroscopy in Ion Channel Research.Advances in experimental medicine and biology · 2026
    Review
  5. Article
  6. Do selectivity filter carbonyls in KJournal of structural biology: X · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Water inside the Selectivity Filter of a KJournal of the American Chemical Society · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. Mechanism of external K+ sensitivity of KCNQ1 channels.The Journal of general physiology · 2023
    Article
  15. Structural basis for severe pain caused by mutations in the S4-S5 linkers of voltage-gated sodium channel NaProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Jing LiDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL.
Jared OstmeyerDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL.
Luis G CuelloDepartment of Cell Physiology and Molecular Biophysics, Texas Tech University Health Sciences Center, Lubbock, TX.ORCID 0000-0001-5192-7568
Eduardo PerozoDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL.
Benoît RouxDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL roux@uchicago.edu.ORCID 0000-0002-5254-2712

Funding

Synthetic Antigen Binder CoreU54GM087519 · NIGMS · UNIVERSITY OF CHICAGO · PI PEROZO, EDUARDO A · 2010 to 2017
$31.9M
TrainingP41GM103712 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FAEDER, JAMES · 2012 to 2021
$16.3M
Computational Studies of Ion Channels - Resubmission 01R01GM062342 · NIGMS · WEILL MEDICAL COLLEGE OF CORNELL UNIV · PI ROUX, BENOIT · 2001 to 2022
$8.7M
HIGH RESOLUTION STRUCTURAL DYNAMICS OF K CHANNELSR01GM057846 · NIGMS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI PEROZO, EDUARDO A · 1998 to 2018
$7.4M
High-resolution crystallographic and functional studies of K+ channel gatingR01GM097159 · NIGMS · TEXAS TECH UNIVERSITY HEALTH SCIS CENTER · PI CUELLO, LUIS GONZALO · 2012 to 2021
$2.7M
Beagle-2S10OD018495 · OD · UNIVERSITY OF CHICAGO · PI FOSTER, IAN · 2014 to 2014
$2.0M
NIGMS NIH HHS P41 GM103712NIGMS NIH HHS R01 GM057846NIGMS NIH HHS R01 GM062342NIGMS NIH HHS R01 GM097159NIGMS NIH HHS U54 GM087519NIH HHS S10 OD018495
6 · The paper itself

Abstract

C-type inactivation is a time-dependent process observed in many K

Indexed as

Bacterial ProteinsMolecular Dynamics SimulationPotassium ChannelsBacterial ProteinsPotassium Channelsprokaryotic potassium channel

Identifiers

PMID30072373
PMCPMC6168234

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.