Evidence map›Paper›PMID 30072225›Full record

ArticleBioorganic & medicinal chemistry letters2018

Synthesis and anticancer activity studies of indolylisoxazoline analogues.

M V S K Chaitanya, P O Venkataramana Reddy, Kumar Nikhil, Anil Kumar, Kavita Shah, Dalip Kumar

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic & medicinal chemistry letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

M V S K ChaitanyaDepartment of Chemistry, Birla Institute of Technology and Science, Pilani 333031, Rajasthan, India.
P O Venkataramana ReddyDepartment of Chemistry, Birla Institute of Technology and Science, Pilani 333031, Rajasthan, India.
Kumar NikhilPurdue University Center for Cancer Research, Purdue University, West Lafayette, IN 47907, United States.
Anil KumarDepartment of Chemistry, Birla Institute of Technology and Science, Pilani 333031, Rajasthan, India.
Kavita ShahPurdue University Center for Cancer Research, Purdue University, West Lafayette, IN 47907, United States. Electronic address: shah23@purdue.edu.
Dalip KumarDepartment of Chemistry, Birla Institute of Technology and Science, Pilani 333031, Rajasthan, India. Electronic address: dalipk@pilani.bits-pilani.ac.in.

Funding

Chemical Genetic Dissection of Aurora A in Promoting EMT and Stem Cells PhenotypeR03CA166912 · NCI · PURDUE UNIVERSITY · PI SHAH, KAVITA · 2013 to 2014
$152k
NCI NIH HHS R03 CA166912
6 · The paper itself

Abstract

A new library of thirteen indolylisoxazolines 6a-m has been synthesized by the treatment of indolylchalcones with hydroxylamine hydrochloride. Evaluation of anticancer activity of indolylisoxazolines 6a-m led to the identification of potent compounds 6c-d, 6i and 6l, with IC

Indexed as

Antineoplastic AgentsApoptosisCell Line, TumorCell MovementCell ProliferationDose-Response Relationship, DrugHEK293 CellsHumansIndolesIsoxazolesMolecular StructureReactive Oxygen SpeciesStructure-Activity RelationshipAntineoplastic AgentsIndolesIsoxazolesReactive Oxygen SpeciesAnticancer activityApoptosisIndole heterocyclesIndolylisoxazolinesIsoxazolines

Identifiers

PMID30072225
PMCPMC8653574

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.