ArticleArthritis research & therapy2018
BATF regulates collagen-induced arthritis by regulating T helper cell differentiation.
Article in Arthritis research & therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 26 citations in OpenAlex.
- Specific features of immune ageing are detected in the earliest stages in rheumatoid arthritis development.EBioMedicine · 2025Article
- Article
- The role of BATF in immune cell differentiation and autoimmune diseases.Biomarker research · 2025Review
- Article
- Article
- scDrugPrio: a framework for the analysis of single-cell transcriptomics to address multiple problems in precision medicine in immune-mediated inflammatory diseases.Genome medicine · 2024Article
- Single-cell chromatin accessibility and transcriptomic characterization of Behcet's disease.Communications biology · 2023Article
- T-helper cells flexibility: the possibility of reprogramming T cells fate.Frontiers in immunology · 2023Review
- Ablation of Basic Leucine Zipper Transcription Factor ATF-Like Potentiates Estradiol to Induce Atopic Dermatitis.Oxidative medicine and cellular longevity · 2022Article
- ZIP8 exacerbates collagen-induced arthritis by increasing pathogenic T cell responses.Experimental & molecular medicine · 2021Article
- Recent insights of T cell receptor-mediated signaling pathways for T cell activation and development.Experimental & molecular medicine · 2020Review
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe recently demonstrated that BATF, a member of the activator protein-1 (AP-1) family, regulates osteoarthritic cartilage destruction. Here, we explored the roles and regulatory mechanisms of BATF in collagen-induced arthritis (CIA) in mice.
methodsCIA and K/BxN serum transfer were used to generate inflammatory arthritis models in wild-type (WT) and Batf
resultsBATF was upregulated in the synovial tissues of joints in which inflammatory arthritis had been caused by CIA or K/BxN serum transfer. The increases in CIA incidence, clinical score, and autoantibody production in CIA-induced WT mice were completely abrogated in the corresponding Batf
conclusionOur findings indicate that BATF crucially mediates CIA by regulating Th cell differentiation without directly affecting the functions of FLS.
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