Evidence map›Paper›PMID 30071863›Full record

ArticleTrials2018

Electronic nicotine devices to aid smoking cessation by alcohol- and drug-dependent clients: protocol for a pilot randomised controlled trial.

Ashleigh Guillaumier, Victoria Manning, Olivia Wynne, Coral Gartner, Ron Borland, Amanda L Baker, Catherine J Segan, Eliza Skelton, Lyndell Moore, Ramez Bathish and 2 more

Open access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 8 pooled it
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 8 syntheses or guidelines pooled it, 13 citations in OpenAlex.

  1. Electronic cigarettes for smoking cessation.The Cochrane database of systematic reviews · 2026
    Pooled it
  2. Electronic cigarettes for smoking cessation.The Cochrane database of systematic reviews · 2025
    Pooled it
  3. Electronic cigarettes for smoking cessation.The Cochrane database of systematic reviews · 2025
    Pooled it
  4. Electronic cigarettes for smoking cessation.The Cochrane database of systematic reviews · 2024
    Pooled it
  5. Electronic cigarettes for smoking cessation.The Cochrane database of systematic reviews · 2022
    Pooled it
  6. Electronic cigarettes for smoking cessation.The Cochrane database of systematic reviews · 2021
    Pooled it
  7. Electronic cigarettes for smoking cessation.The Cochrane database of systematic reviews · 2021
    Pooled it
  8. Electronic cigarettes for smoking cessation.The Cochrane database of systematic reviews · 2020
    Pooled it
  9. Trial
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Ashleigh GuillaumierSchool of Medicine & Public Health, University of Newcastle, Callaghan, Australia.
Victoria ManningEastern Health Clinical School, Monash University, Box Hill, VIC, Australia.
Olivia WynneSchool of Medicine & Public Health, University of Newcastle, Callaghan, Australia.ORCID http://orcid.org/0000-0001-5238-3080
Coral GartnerFaculty of Medicine, School of Public Health, The University of Queensland, St Lucia, QLD, Australia.
Ron BorlandThe Cancer Council Victoria, Melbourne, Victoria, Australia.
Amanda L BakerSchool of Medicine & Public Health, University of Newcastle, Callaghan, Australia.
Catherine J SeganThe Cancer Council Victoria, Melbourne, Victoria, Australia.
Eliza SkeltonSchool of Medicine & Public Health, University of Newcastle, Callaghan, Australia.
Lyndell MooreSchool of Medicine & Public Health, University of Newcastle, Callaghan, Australia.
Ramez BathishEastern Health Clinical School, Monash University, Box Hill, VIC, Australia.
Dan I LubmanEastern Health Clinical School, Monash University, Box Hill, VIC, Australia.
Billie BonevskiSchool of Medicine & Public Health, University of Newcastle, Callaghan, Australia. billie.bonevski@newcastle.edu.au.
University of Newcastle Australia · AUEastern Health · AUCancer Council Victoria · AUThe University of Melbourne · AUThe University of Queensland · AU

Funding

VicHealth 2016-0096
6 · The paper itself

Abstract

backgroundUp to 95% of people entering treatment for use of alcohol or other drugs (AOD) smoke tobacco. Smokers receiving treatment for AOD use are interested in quitting and make quit attempts, but relapse is more common and rapid compared with the general population of smokers. New ways to address smoking in this population are needed. Electronic nicotine devices (ENDs) or electronic cigarettes hold significant potential as both cessation aids and harm reduction support. This study focuses on the potential of ENDs to facilitate smoking cessation and to sustain it in the medium term among people in treatment for AOD use. The aim of this trial is to explore the effectiveness, feasibility and acceptability of ENDs for smoking cessation compared with combination nicotine replacement therapy (NRT) for clients after discharge from a smoke-free AOD residential withdrawal service. METHODS/

designThe study is a pragmatic randomised controlled trial. In total, 100 participants will be recruited following admission to a smoke-free residential withdrawal service in Melbourne, Australia. Participants will complete a baseline survey and be randomised to either the END group (n = 50) or the NRT group (n = 50) prior to discharge. Both groups will receive telephone counselling support from quitline. Follow-up measures will be assessed at 6 and 12 weeks following discharge. The primary outcome is continuous abstinence from smoking at 12 weeks post discharge. Secondary outcomes include: 7-day point prevalence from smoking, point prevalence abstinence from all nicotine (including NRT and ENDs), cravings and withdrawal, time to relapse, and treatment adherence (use of NRT, ENDs and quitline). DISCUSSION: This is the first randomised controlled trial to assess the effectiveness and acceptability of ENDs within a population dependent on AOD, a priority group with very high levels of smoking. The research will test a model of how to incorporate novel smoking cessation support into a period of high treatment receptiveness.

trial registrationAustralian New Zealand Clinical Trial Registry, ACTRN12617000849392 . Registered on 8 June 2017.

Indexed as

Electronic Nicotine Delivery SystemsAdministration, InhalationAlcoholicsAlcoholismClinical Trials, Phase II as TopicCounselingDrug UsersFeasibility StudiesHumansNicotineNicotinic AgonistsPilot ProjectsPragmatic Clinical Trials as TopicRecurrenceSmokingSmoking CessationNicotineNicotinic AgonistsAlcohol and other drugsElectronic cigarettesNicotine replacement therapySmoking cessation

Identifiers

PMID30071863
PMCPMC6090830
OpenAlexW2886443943

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.