Evidence map›Paper›PMID 30071840›Full record

ArticleBMC gastroenterology2018

Gall bladder wall thickening as non-invasive screening parameter for esophageal varices - a comparative endoscopic - sonographic study.

Birgit Tsaknakis, Rawan Masri, Ahmad Amanzada, Golo Petzold, Volker Ellenrieder, Albrecht Neesse, Steffen Kunsch

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Birgit TsaknakisDepartment Gastroenterology and Gastrointestinal Oncology, University Medical Centre Goettingen Georg-August-University, Robert-Koch-Str. 40, 37075, Goettingen, Germany.
Rawan MasriDepartment Gastroenterology and Gastrointestinal Oncology, University Medical Centre Goettingen Georg-August-University, Robert-Koch-Str. 40, 37075, Goettingen, Germany.
Ahmad AmanzadaDepartment Gastroenterology and Gastrointestinal Oncology, University Medical Centre Goettingen Georg-August-University, Robert-Koch-Str. 40, 37075, Goettingen, Germany.
Golo PetzoldDepartment Gastroenterology and Gastrointestinal Oncology, University Medical Centre Goettingen Georg-August-University, Robert-Koch-Str. 40, 37075, Goettingen, Germany.
Volker EllenriederDepartment Gastroenterology and Gastrointestinal Oncology, University Medical Centre Goettingen Georg-August-University, Robert-Koch-Str. 40, 37075, Goettingen, Germany.
Albrecht NeesseDepartment Gastroenterology and Gastrointestinal Oncology, University Medical Centre Goettingen Georg-August-University, Robert-Koch-Str. 40, 37075, Goettingen, Germany. albrecht.neesse@med.uni-goettingen.de.
Steffen KunschDepartment Gastroenterology and Gastrointestinal Oncology, University Medical Centre Goettingen Georg-August-University, Robert-Koch-Str. 40, 37075, Goettingen, Germany.
University of Göttingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe mortality due to hemorrhage of esophageal varices (EV) is still high. The predominant cause for EV is liver cirrhosis, which has a high prevalence in Western Europe. Therefore, non-invasive screening markers for the presence of EV are of interest. Here, we aim to investigate whether non-inflammatory gall bladder wall thickening (GBWT) may serve as predictor for the presence of EV in comparison and combination with other non-invasive clinical and laboratory parameters.

methodsOne hundred ninety four patients were retrospectively enrolled in the study. Abdominal ultrasound, upper endoscopy and blood tests were evaluated. GBWT, spleen size and the presence of ascites were evaluated by ultrasound. Platelet count and Child-Pugh-score were also recorded. The study population was categorized in two groups: 122 patients without esophageal varices (non EV) compared to 72 patients with EV were analyzed by uni-and multivariate analysis.

resultsIn the EV group 46% showed a non-inflammatory GBWT of ≥4 mm, compared to 12% in the non-EV group (p < 0.01). GBWT was significantly higher in EV patients compared to the non-EV group (mean: 4.4 mm vs. 2.8 mm, p < 0.0001), and multivariate analysis confirmed GBWT as independent predictor for EV (p < 0.04). The platelets/GBWT ratio (cut-off > 46.2) had a sensitivity and specificity of 78 and 86%, PPV 76% and NPV of 87%, and ROC analysis calculated the AUC of 0.864 (CI 0.809-0.919).

conclusionsGBWT occurs significantly more often in patients with EV. However, because of the low sensitivity, combination with other non-invasive parameters such as platelet count is recommended.

Indexed as

AdolescentAdultAgedAged, 80 and overEndoscopy, GastrointestinalEsophageal and Gastric VaricesFemaleGallbladderHumansHypertension, PortalLiverLiver DiseasesMaleMiddle AgedRetrospective StudiesSpleenChild-Pugh-scoreCirrhosisEsophageal varicesGall bladder wallLiver diseaseNon-invasive parameterPortal hypertensionUltrasound parameter

Identifiers

PMID30071840
PMCPMC6090930
OpenAlexW2885592757

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.