ArticleKorean journal of anesthesiology2018
Comparison of priming versus slow injection for reducing etomidate-induced myoclonus: a randomized controlled study.
Article in Korean journal of anesthesiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.
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Who cites it
7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 13 citations in OpenAlex.
- Comparative efficacy and safety of 20 intravenous pharmaceutical intervention for prevention of etomidate-induced myoclonus: a systematic review and Bayesian network meta-analysis.Frontiers in pharmacology · 2024Pooled it
- Comparison of the Effectiveness of Various Drug Interventions to Prevent Etomidate-Induced Myoclonus: A Bayesian Network Meta-Analysis.Frontiers in medicine · 2022Pooled it
- Effect of Oliceridine Pretreatment on Etomidate-Induced Myoclonus: A Proof-of-Concept Randomized Trial.Drug design, development and therapy · 2026Trial
- Effect of etomidate added to propofol target-controlled infusion in bidirectional endoscopy: A randomized clinical trial.World journal of gastrointestinal endoscopy · 2025Trial
- Effect of Pretreatment with a Small Dose of Esketamine on Myoclonus Induced by Etomidate: A Randomized Controlled Trial.Drug design, development and therapy · 2024Trial
- To compare the efficacy of three techniques in reducing etomidate-induced myoclonus - A randomised controlled trial.Indian journal of anaesthesia · 2025Article
- Comparison of Premedication with Low-Dose Midazolam Versus Etomidate for Reduction of Etomidate-Induced Myoclonus During General Anesthesia for Electroconvulsive Therapy: A Randomized Clinical Trial.Anesthesiology and pain medicine · 2019Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEtomidate injection is often associated with myoclonus. Etomidate injection technique influences the incidence of myoclonus. This study was designed to clarify which of the two injection techniques-slow injection or priming with etomidate-is more effective in reducing myoclonus.
methodsThis prospective randomized controlled study was conducted on 189 surgical patients allocated to three study groups. Control group (Group C, n = 63) received 0.3 mg/kg etomidate (induction dose) over 20 s. Priming group (Group P, n = 63) received pretreatment with 0.03 mg/kg etomidate, followed after 1 min by an etomidate induction dose over 20 s. Slow injection group (Group S, n = 63) received etomidate (2 mg/ml) induction dose over 2 min. The patients were observed for occurrence and severity of myoclonus for 3 min from the start of injection of the induction dose.
resultsThe incidence of myoclonus in Group P (38/63 [60.3%], 95% CI: 48.0-71.5) was significantly lower than in Group C (53/63 [84.1%], 95% CI: 72.9-91.3, P = 0.003) and Group S (49/63 [77.8%], 95% CI: 66.0-86.4, P = 0.034). Myoclonus of moderate or severe grade occurred in significantly more patients in Group C (68.3%) than in Group P (36.5%, P < 0.001) and Group S (50.8%, P = 0.046), but the difference between Groups P and S was not significant (P = 0.106).
conclusionsPriming is more effective than slow injection in reducing the incidence of myoclonus, but their effects on the severity of myoclonus are comparable.
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