Evidence map›Paper›PMID 30071616›Full record

ArticleMolecules (Basel, Switzerland)2018

Phytochemical Composition and Cytotoxic Effects on Liver Hepatocellular Carcinoma Cells of Different Berries Following a Simulated In Vitro Gastrointestinal Digestion.

Francesca Giampieri, Sadia Afrin, Derek Stewart, Gordon J McDougall, Rex Brennan, Lesley Blyth, Massimiliano Gasparrini, Luca Mazzoni, Franco Capocasa, Josè Miguel Alvarez-Suarez and 9 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Review
  3. Blueberry (Foods (Basel, Switzerland) · 2024
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 6 institutions in 6 countries.

Francesca GiampieriDipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche-Sez. Biochimica, Facoltà di Medicina, Università Politecnica delle Marche, 60131 Ancona, Italy. f.giampieri@univpm.it.ORCID 0000-0002-8151-9132
Sadia AfrinDipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche-Sez. Biochimica, Facoltà di Medicina, Università Politecnica delle Marche, 60131 Ancona, Italy. dolla.bihs@gmail.com.ORCID 0000-0001-5063-9900
Derek StewartThe James Hutton Institute, Dundee DD2 5DA, UK. Derek.Stewart@hutton.ac.uk.ORCID 0000-0001-9838-4265
Gordon J McDougallThe James Hutton Institute, Dundee DD2 5DA, UK. Gordon.McDougall@hutton.ac.uk.
Rex BrennanThe James Hutton Institute, Dundee DD2 5DA, UK. rex.brennan@hutton.ac.uk.
Lesley BlythThe James Hutton Institute, Dundee DD2 5DA, UK. lesley.blyth@hutton.ac.uk.
Massimiliano GasparriniDipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche-Sez. Biochimica, Facoltà di Medicina, Università Politecnica delle Marche, 60131 Ancona, Italy. m.gasparrini@univpm.it.ORCID 0000-0001-9738-2663
Luca MazzoniDipartimento di Scienze Agrarie, Alimentari e Ambientali, Università Politecnica delle Marche, Via Ranieri 65, 60131 Ancona, Italy. l.mazzoni@univpm.it.
Franco CapocasaDipartimento di Scienze Agrarie, Alimentari e Ambientali, Università Politecnica delle Marche, Via Ranieri 65, 60131 Ancona, Italy. f.capocasa@univpm.it.
Josè Miguel Alvarez-SuarezFacultad de Ingeniería y Ciencias Agropecuarias (FICA), Grupo de Investigación en Biotecnología Aplicada a Biomedicina (BIOMED), Universidad de Las Américas, José Queri y Ave. de los Granados, Quito 170513, Ecuador. jose.alvarez@udla.edu.ec.ORCID 0000-0001-8509-1498
Stefano BompadreDipartimento Scienze Biomediche e Sanita' Pubblica, Facoltà di Medicina, Università Politecnica delle Marche, 60131 Ancona, Italy. s.bompadre@univpm.it.
Pedro Nogueira Brás de OliveiraInstituto Nacional de Investigacao Agraria e Veterinaria (INIAV), 2780-113 Carcavelos, Portugal. pedro.oliveira@iniav.pt.
Claudia N SantosiBET, Instituto de Biologia Experimental e Tecnológica, Apartado 12, 2781-901 Oeiras, Portugal. dsb.lab.itqb@gmail.com.
Manuel MasiasCenter for Nutrition & Health. CITICAN, Universidad Europea del Atlántico, Parque Científico y Tecnológico de Cantabria C/Isabel Torres 21, 39011 Santander, Spain. Manuel.masias@uneatlantico.es.
Pablo AgudoCenter for Nutrition & Health. CITICAN, Universidad Europea del Atlántico, Parque Científico y Tecnológico de Cantabria C/Isabel Torres 21, 39011 Santander, Spain. pablo.agudo@uneatlantico.es.ORCID 0000-0002-9436-2082
Jorge CrespoCenter for Nutrition & Health. CITICAN, Universidad Europea del Atlántico, Parque Científico y Tecnológico de Cantabria C/Isabel Torres 21, 39011 Santander, Spain. jorge.crespo@uneatlantico.es.ORCID 0000-0001-7589-5337
Bruno MezzettiDipartimento di Scienze Agrarie, Alimentari e Ambientali, Università Politecnica delle Marche, Via Ranieri 65, 60131 Ancona, Italy. b.mezzetti@univpm.it.
Tamara Y Forbes-HernándezDipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche-Sez. Biochimica, Facoltà di Medicina, Università Politecnica delle Marche, 60131 Ancona, Italy. tamara.forbe@gmail.com.ORCID 0000-0001-7021-9276
Maurizio BattinoDipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche-Sez. Biochimica, Facoltà di Medicina, Università Politecnica delle Marche, 60131 Ancona, Italy. m.a.battino@univpm.it.ORCID 0000-0002-7250-1782
Marche Polytechnic University · ITJames Hutton Institute · GBUniversidad Europea del Atlántico · ESInstituto de Biologia Experimental e Tecnológica · PTInstituto Nacional de Investigação Agrária e Veterinária · PTUniversidad de Las Américas · EC

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Berry fruits are rich in nutrients and polyphenols, providing potential health benefits. Understanding the factors that affect their bioavailability is becoming of utmost importance for evaluating their biological significance and efficacy as functional food. In this study, the phytochemical composition and the total antioxidant capacity of different varieties of five berries (blackberry, blackcurrant, blueberry, raspberry, and strawberry) were evaluated after an in vitro gastrointestinal digestion process. The cultivar of each berry that showed the higher content of total phenols and flavonoids was selected to study its cytotoxic effect on human hepatoma cells. Digestion resulted in a high reduction (

Indexed as

Blueberry PlantsCarcinoma, HepatocellularCell Line, TumorCell SurvivalFlavonoidsFragariaFruitHumansLiver NeoplasmsPhenolsPolyphenolsRubusFlavonoidsPhenolsPolyphenolsberrybioavailabilitycytotoxicityin vitro gastrointestinal digestionpolyphenols

Identifiers

PMID30071616
PMCPMC6222530
OpenAlexW2887303257

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.