Evidence map›Paper›PMID 30071584›Full record

ArticlePharmaceutics2018

Useful In Vitro Techniques to Evaluate the Mucoadhesive Properties of Hyaluronic Acid-Based Ocular Delivery Systems.

Angélica Graça, Lídia Maria Gonçalves, Sara Raposo, Helena Margarida Ribeiro, Joana Marto

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
7.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 76 citations in OpenAlex.

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  17. Spray Film-Forming systems as promising topicalSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Angélica GraçaLaboratório Edol-Produtos Farmacêuticos, S.A., 2595-225 Linda-a-Velha, Portugal. angelicagraca@campus.ul.pt.
Lídia Maria GonçalvesResearch Institute for Medicine (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, 1649-003 Lisbon, Portugal. lgoncalves@ff.ulisboa.pt.ORCID 0000-0002-6799-2740
Sara RaposoLaboratório Edol-Produtos Farmacêuticos, S.A., 2595-225 Linda-a-Velha, Portugal. sraposo@edol.pt.
Helena Margarida RibeiroResearch Institute for Medicine (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, 1649-003 Lisbon, Portugal. hribeiro@campus.ul.pt.ORCID 0000-0002-2429-7991
Joana MartoLaboratório Edol-Produtos Farmacêuticos, S.A., 2595-225 Linda-a-Velha, Portugal. jmmarto@ff.ulisboa.pt.ORCID 0000-0001-5523-5622
University of Lisbon · PTLaboratório Edol (Portugal) · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polymer-based eye drops are the most used drug delivery system to treat dry eye disease (DED). Therefore, the mucoadhesion between the polymer and the ocular mucin is crucial to ensure the efficacy of the treatment. In this context, the present study aimed to evaluate the potential use of in vitro methods to study the mucoadhesion of eye drop solutions and, specifically to evaluate the efficacy of two hyaluronic acid-based formulations (HA), HA 0.15% and 0.30% (

Indexed as

dry eye diseaseeye dropshyaluronic acidin vitro testsmedical devicesmucoadhesion

Identifiers

PMID30071584
PMCPMC6161121
OpenAlexW2886720986

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.