Evidence map›Paper›PMID 30071486›Full record

ArticleJournal of the mechanical behavior of biomedical materials2018

An investigation of the anisotropic mechanical properties and anatomical structure of porcine atrioventricular heart valves.

Samuel Jett, Devin Laurence, Robert Kunkel, Anju R Babu, Katherine Kramer, Ryan Baumwart, Rheal Towner, Yi Wu, Chung-Hao Lee

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the mechanical behavior of biomedical materials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 72 citations in OpenAlex.

  1. Article
  2. Chordae Rupture Alters Tricuspid Valve Leaflet Biomechanics.Cardiovascular engineering and technology · 2026
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  17. Clinical Impact of Computational Heart Valve Models.Materials (Basel, Switzerland) · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Samuel JettSchool of Aerospace and Mechanical Engineering, The University of Oklahoma, 865 Asp Ave., Felgar Hall Rm. 219 C, Norman, OK 73019, USA.
Devin LaurenceSchool of Aerospace and Mechanical Engineering, The University of Oklahoma, 865 Asp Ave., Felgar Hall Rm. 219 C, Norman, OK 73019, USA.
Robert KunkelSchool of Aerospace and Mechanical Engineering, The University of Oklahoma, 865 Asp Ave., Felgar Hall Rm. 219 C, Norman, OK 73019, USA.
Anju R BabuSchool of Aerospace and Mechanical Engineering, The University of Oklahoma, 865 Asp Ave., Felgar Hall Rm. 219 C, Norman, OK 73019, USA.
Katherine KramerSchool of Aerospace and Mechanical Engineering, The University of Oklahoma, 865 Asp Ave., Felgar Hall Rm. 219 C, Norman, OK 73019, USA.
Ryan BaumwartCenter for Veterinary Health Sciences, Oklahoma State University, 208 S. McFarland Street, Stillwater, OK 74078, USA.
Rheal TownerAdvanced Magnetic Resonance Center, MS 60, Oklahoma Medical Research Foundation 825 N.E. 13th Street, Oklahoma City, OK 73104, USA.
Yi WuSchool of Aerospace and Mechanical Engineering, The University of Oklahoma, 865 Asp Ave., Felgar Hall Rm. 219 C, Norman, OK 73019, USA.
Chung-Hao LeeSchool of Aerospace and Mechanical Engineering, The University of Oklahoma, 865 Asp Ave., Felgar Hall Rm. 219 C, Norman, OK 73019, USA; Institute for Biomedical Engineering, Science and Technology (IBEST), The University of Oklahoma, Norman, OK 73019, USA. Electronic address: ch.lee@ou.edu.
University of Oklahoma · USOklahoma Medical Research Foundation · USOklahoma State University · US

Funding

American Heart Association-American Stroke Association 16SDG27760143
6 · The paper itself

Abstract

Valvular heart diseases are complex disorders, varying in pathophysiological mechanism and affected valve components. Understanding the effects of these diseases on valve functionality requires a thorough characterization of the mechanics and structure of the healthy heart valves. In this study, we performed biaxial mechanical experiments with extensive testing protocols to examine the mechanical behaviors of the mitral valve and tricuspid valve leaflets. We also investigated the effect of loading rate, testing temperatures, species (porcine versus ovine hearts), and age (juvenile vs adult ovine hearts) on the mechanical responses of the leaflet tissues. In addition, we evaluated the structure of chordae tendineae within each valve and performed histological analysis on each atrioventricular leaflet. We found all tissues displayed a characteristic nonlinear anisotropic mechanical response, with radial stretches on average 30.7% higher than circumferential stretches under equibiaxial physiological loading. Tissue mechanical responses showed consistent mechanical stiffening in response to increased loading rate and minor temperature dependence in all five atrioventricular heart valve leaflets. Moreover, our anatomical study revealed similar chordae quantities in the porcine mitral (30.5 ± 1.43 chords) and tricuspid valves (35.3 ± 2.45 chords) but significantly more chordae in the porcine than the ovine valves (p < 0.010). Our histological analyses quantified the relative thicknesses of the four distinct morphological layers in each leaflet. This study provides a comprehensive database of the mechanics and structure of the atrioventricular valves, which will be beneficial to development of subject-specific atrioventricular valve constitutive models and toward multi-scale biomechanical investigations of heart valve function to improve valvular disease treatments.

Indexed as

Mechanical PhenomenaAnimalsAnisotropyBiomechanical PhenomenaHeart AtriaHeart ValvesHeart VentriclesMaterials TestingSheepSwineTemperatureWeight-BearingBiaxial mechanical testingMorphological analysisSoft tissue biomechanics and microstructureThe mitral and tricuspid valves

Identifiers

PMID30071486
PMCPMC8008704
OpenAlexW2884018697

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.