ArticleBrain, behavior, and immunity2018
Post-operative pain in mice is prolonged by diet-induced obesity and rescued by dietary intervention.
Article in Brain, behavior, and immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 21 citations in OpenAlex.
- Diet-induced obesity exacerbates and prolongs postoperative pain via peripheral DRG transcriptional changes in rats.Journal of dental anesthesia and pain medicine · 2026Article
- Early Post-discharge Pain Trajectories After Thoracoscopic Sublobar Resection for Stage IA Non-small Cell Lung Cancer.Annals of surgical oncology · 2026Observational
- Article
- Relationship between diet and postoperative pain: A scoping review.Journal of anesthesia and translational medicine · 2024Review
- Racial Differences in Pain, Nutrition, and Oxidative Stress.Pain and therapy · 2022Review
- High-fat diet and post-operative pain: Why the hospital cafeteria may matter.Brain, behavior, and immunity · 2018Article
- An adolescent rat model of vincristine-induced peripheral neuropathy.Neurobiology of pain (Cambridge, Mass.)Article
- Diet, body weight and pain susceptibility - A systematic review of preclinical studies.Neurobiology of pain (Cambridge, Mass.)Review
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The prevalence of obesity has increased at an alarming rate during past decades. Obesity is associated with pathophysiological disorders that can evolve and increase the risk of heart disease, diabetes and hypertension. While the impact of diabetes on post-operative recovery is now known, the consequences of obesity on post-operative pain remain much less explored. Here, we show that obesity affects post-operative pain resolution and leads to a chronic pain state in mice. Several mechanisms were identified as implicated in the prolonged post-operative pain. Indeed, we found that following a hind paw incision, high fat diet prolonged glial cell activation in the spinal cord. It also altered the expression of neurotrophins and increased inflammatory and endoplasmic reticulum stress markers in both central and peripheral nervous systems. Moreover, we show that a dietary intervention, leading to weight reduction and decreased inflammation, was able to restore normal pain sensitivity in mice suffering from chronic pain for more than 10 weeks. In conclusion, our data demonstrate that obesity is responsible for pain chronicization. This is clearly of importance in a clinical post-operative setting.
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