ArticleThe Annals of thoracic surgery2018
Electroencephalographic Response to Deep Hypothermic Circulatory Arrest in Neonatal Swine and Humans.
Article in The Annals of thoracic surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 19 citations in OpenAlex.
- A novel translational bioinformatics framework for facilitating multimodal data analyses in preclinical models of neurological injury.Scientific reports · 2024Article
- Carbon monoxide as a cellular protective agent in a swine model of cardiac arrest protocol.PloS one · 2024Article
- Investigation of Cerebral Mitochondrial Injury in a Porcine Survivor Model of Carbon Monoxide Poisoning.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2024Article
- Article
- Perioperative electroencephalography in cardiac surgery with hypothermic circulatory arrest: a narrative review.Interactive cardiovascular and thoracic surgery · 2022Review
- Low frequency power in cerebral blood flow is a biomarker of neurologic injury in the acute period after cardiac arrest.Resuscitation · 2022Article
- Correlation of Cerebral Microdialysis with Non-Invasive Diffuse Optical Cerebral Hemodynamic Monitoring during Deep Hypothermic Cardiopulmonary Bypass.Metabolites · 2022Article
- Alterations in cerebral and cardiac mitochondrial function in a porcine model of acute carbon monoxide poisoning.Clinical toxicology (Philadelphia, Pa.) · 2021Article
- Part II. Comparison of Neurodevelopmental Outcomes Between Normothermic and Hypothermic Pediatric Cardiopulmonary Bypass.Frontiers in pediatrics · 2019Article
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
backgroundPiglets are used to study neurologic effects of deep hypothermic circulatory arrest (DHCA), but no studies have compared human and swine electroencephalogram (EEG) responses to DHCA. The importance of isoelectricity before circulatory arrest is not fully known in neonates. We compared the EEG response to DHCA in human neonates and piglets.
methodsWe recorded 2 channel, left and right centroparietal, subdermal EEG in 10 neonatal patients undergoing operations involving DHCA and 10 neonatal piglets that were placed on cardiopulmonary bypass and underwent a simulated procedure using DHCA. EEG waveforms were analyzed for the presence and extent of burst suppression and isoelectricity by automated moving window analysis. The patients were monitored with 16-channel array EEG for 48 hours postoperatively and underwent postoperative brain magnetic resonance imaging.
resultsAfter induction of anesthesia, humans and piglets both displayed slowing or brief suppression, then mild burst suppression, and then severe burst suppression during cooling. All piglets subsequently achieved isoelectricity at 22.4° ± 6.9°C, whereas only 1 human did at 20.2°C. Piglets and humans emerged from severe, mild, and then brief suppression patterns during rewarming. Among the patients, there were no seizures during postoperative monitoring and 1 instance of increased white matter injury on postoperative magnetic resonance imaging.
conclusionsOur data suggest that current cooling strategies may not be sufficient to eliminate all EEG activity before circulatory arrest in humans but are sufficient in swine. This important difference between the swine and human response to DHCA should be considered when using this model.
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