ArticlePloS one2018
Age-related changes in estradiol and longitudinal associations with fat mass in men.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 33 citations in OpenAlex.
- Long-term endurance running training and testosterone daily variation in ageing men; a comparative cross-sectional study.Experimental physiology · 2026Article
- Altered Expression of Aromatase and Estrogen Receptors in Adipose Tissue From Men With Obesity or Type 2 Diabetes.The Journal of clinical endocrinology and metabolism · 2025Article
- A Review on Testosterone: Estradiol Ratio-Does It Matter, How Do You Measure It, and Can You Optimize It?The world journal of men's health · 2025Review
- Effect of 17β-Estradiol on Endothelial Cell Expression of Inflammation- Related MicroRNA.MicroRNA (Shariqah, United Arab Emirates) · 2025Article
- Metabolic impact of endogenously produced estrogens by adipose tissue in females and males across the lifespan.Frontiers in endocrinology · 2025Review
- Effect of host breeds on gut microbiome and fecal metabolome in commercial pigs.BMC veterinary research · 2024Article
- Estrogen counteracts age-related decline in beige adipogenesis through the NAMPT-regulated ER stress response.Nature aging · 2024Article
- The Loss of Estradiol by Androgen Deprivation in Prostate Cancer Patients Shows the Importance of Estrogens in Males.Journal of the Endocrine Society · 2024Review
- Hormonal patterns in men with prediabetes and diabetes in NHANES III: possible links with prostate cancer.Cancer causes & control : CCC · 2022Article
- The Translational Role of Animal Models for Estrogen-Related Functional Bladder Outlet Obstruction and Prostatic Inflammation.Veterinary sciences · 2022Review
- Interactive Effects of Unhealthy Lifestyle Behaviors on Testicular Function among Healthy Adult Men: A Cross-Sectional Study in Taiwan.International journal of environmental research and public health · 2021Article
- Serum Omentin Levels in Patients with Prostate Cancer and Associations with Sex Steroids and Metabolic Syndrome.Journal of clinical medicine · 2020Article
- The Role of Diet and Weight Loss in Improving Secondary Hypogonadism in Men with Obesity with or without Type 2 Diabetes Mellitus.Nutrients · 2019Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextIn men, circulating 17β-estradiol originates primarily from peripheral aromatization of testosterone particularly in adipose tissue. The effect of ageing and obesity on circulating estradiol remains unclear.
objectiveDetermine five-year changes in serum estradiol and the association with testosterone and fat mass in Australian men.
designLongitudinal cohort study. At baseline and five-year follow-up, socio-demographic and health-related data including behaviors, chronic conditions, and medication use were collected by questionnaire. Estradiol and testosterone were assayed by liquid chromatography-tandem mass spectrometry and sex hormone-binding globulin by immunochemiluminescent assay. Fat mass was assessed by dual-energy X-ray absorptiometry.
participantsCommunity-dwelling men aged 35 years and older at enrollment, resident in the northern and western suburbs of Adelaide without established disease of, or medications affecting, the hypothalamus-pituitary-gonadal axis (n = 725).
main outcome measuresThe dependence of change in serum estradiol over five years on age, testosterone and fat mass after adjustment for multiple confounders.
resultsAt baseline, mean age was 53.0 ± 10.8 years. Mean serum estradiol levels at baseline and five-year follow-up were 94.9 ± 34.8 and 89.4 ± 30.4 pmol/L respectively (-1.1 pmol/L/year). On multivariable analyses, estradiol change was associated with changes in testosterone (B-estimate = 2.719, standard error = 0.369, p˂0.001), but not age or total fat mass. Change in testosterone/estradiol ratio was inversely associated with change in fat mass (B = -1.450, SE = 0.575, p = 0.012), and this was consistent across quartiles of fat mass change.
conclusionsIn healthy men, circulating estradiol is primarily dependent on testosterone. With increasing fat mass, estradiol decreases less than testosterone. From a clinical standpoint these data indicate that obesity is associated with a change in the testosterone to estradiol ratio, but a change in estradiol does not occur unless some other pathology is present.
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