Evidence map›Paper›PMID 30070633›Full record

ArticleeLife2018

Reactivation of RNA metabolism underlies somatic restoration after adult reproductive diapause in

Nikolay Burnaevskiy, Shengying Chen, Miguel Mailig, Anthony Reynolds, Shruti Karanth, Alexander Mendenhall, Marc Van Gilst, Matt Kaeberlein

Open access · goldAbstract read
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.2field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Condition-dependent effects of knockdown of autophagy onbioRxiv : the preprint server for biology · 2025
    Article
  4. Article
  5. Article
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  7. Article
  8. Review
  9. Review
  10. Biology of theGenetics · 2019
    Review
  11. Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Nikolay BurnaevskiyDepartment of Pathology, University of Washington, Seattle, United States.ORCID http://orcid.org/0000-0003-1885-8999
Shengying ChenDepartment of Pathology, University of Washington, Seattle, United States.
Miguel MailigDepartment of Pathology, University of Washington, Seattle, United States.
Anthony ReynoldsDepartment of Pathology, University of Washington, Seattle, United States.
Shruti KaranthDepartment of Pathology, University of Washington, Seattle, United States.
Alexander MendenhallDepartment of Pathology, University of Washington, Seattle, United States.ORCID http://orcid.org/0000-0002-4716-7671
Marc Van GilstDepartment of Anesthesiology and Pain Medicine, University of Washington, Seattle, United States.
Matt KaeberleinDepartment of Pathology, University of Washington, Seattle, United States.ORCID http://orcid.org/0000-0002-1311-3421
University of Washington · US

Funding

SPECIFICITY OF OXYGEN DNA DAMAGE AND MUTAGENESISP01AG001751 · NIA · UNIVERSITY OF WASHINGTON · PI RABINOVITCH, PETER S · 1985 to 2021
$29.6M
GENETIC APPROACHES TO AGING RESEARCHT32AG000057 · NIA · UNIVERSITY OF WASHINGTON · PI RABINOVITCH, PETER S · 1985 to 2019
$14.2M
Mechanisms of Life Span Extension By Dietary DeprivationR01AG031108 · NIA · UNIVERSITY OF WASHINGTON · PI KAEBERLEIN, MATT, VAN GILST, MARC R · 2008 to 2019
$3.2M
Causes and consequences of lifespan biomarker variation in Caenorhabditis elegansR00AG045341 · NIA · UNIVERSITY OF WASHINGTON · PI MENDENHALL, ALEXANDER RICHARD · 2016 to 2018
$747k
NIA NIH HHS P01 AG001751NIA NIH HHS R00 AG045341NIA NIH HHS R00AG045341NIA NIH HHS R01 AG031108NIA NIH HHS R01AG031108NIA NIH HHS T32 AG000057NIA NIH HHS T32AG000057
6 · The paper itself

Abstract

The mechanisms underlying biological aging are becoming recognized as therapeutic targets to delay the onset of multiple age-related morbidities. Even greater health benefits can potentially be achieved by halting or reversing age-associated changes.

Indexed as

AnimalsCaenorhabditis elegansDeoxyuridineDiapauseDNA, MitochondrialGerm CellsLongevityReproductionRNAStem Cells5-fluoro-2'-deoxyuridineDeoxyuridineDNA, MitochondrialRNAC. eleganscell biologydiapauseFUDRgermline stem cellsrejuvenationribosomal RNAstarvation

Identifiers

PMID30070633
PMCPMC6089596
OpenAlexW2886820214

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.