Evidence map›Paper›PMID 30070404›Full record

ArticleCell proliferation2018

Treatment of β

Yudan Fang, Yan Cheng, Dan Lu, Xiuli Gong, Guanheng Yang, Zhijuan Gong, Yiwen Zhu, Xiao Sang, Shuyue Fan, Jingzhi Zhang and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell proliferation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Precision Editing as a Therapeutic Approach for β-Hemoglobinopathies.International journal of molecular sciences · 2023
    Review
  5. Genome Editing and Diabetic Cardiomyopathy.Advances in experimental medicine and biology · 2023
    Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Nucleic Acid Therapy for β-Thalassemia.Biologics : targets & therapy · 2020
    Review
  12. Review
  13. Review
  14. Treatment of βCell proliferation · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Yudan FangShanghai Children's Hospital, Shanghai Institute of Medical Genetics, Shanghai Jiao Tong University, Shanghai, China.
Yan ChengShanghai Children's Hospital, Shanghai Institute of Medical Genetics, Shanghai Jiao Tong University, Shanghai, China.
Dan LuShanghai Children's Hospital, Shanghai Institute of Medical Genetics, Shanghai Jiao Tong University, Shanghai, China.
Xiuli GongShanghai Children's Hospital, Shanghai Institute of Medical Genetics, Shanghai Jiao Tong University, Shanghai, China.
Guanheng YangShanghai Children's Hospital, Shanghai Institute of Medical Genetics, Shanghai Jiao Tong University, Shanghai, China.
Zhijuan GongShanghai Children's Hospital, Shanghai Institute of Medical Genetics, Shanghai Jiao Tong University, Shanghai, China.
Yiwen ZhuShanghai Children's Hospital, Shanghai Institute of Medical Genetics, Shanghai Jiao Tong University, Shanghai, China.
Xiao SangShanghai Children's Hospital, Shanghai Institute of Medical Genetics, Shanghai Jiao Tong University, Shanghai, China.
Shuyue FanDepartment of Histo-Embryology, Genetics and Developmental Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jingzhi ZhangShanghai Children's Hospital, Shanghai Institute of Medical Genetics, Shanghai Jiao Tong University, Shanghai, China.
Fanyi ZengShanghai Children's Hospital, Shanghai Institute of Medical Genetics, Shanghai Jiao Tong University, Shanghai, China.ORCID http://orcid.org/0000-0001-7053-1614
Shanghai Jiao Tong University · CN

Funding

Experimental Animals Project of Shanghai Municipality 18140901600Experimental Animals Project of Shanghai Municipality 18140901601National Basic Research Program of China 2014CB964701National Basic Research Program of China 2014CB964703National Natural Science Foundation of China 81570172Project of Academician Workstation at KingMed Diagnostics 2017B090904030Shanghai Municipal Commission of Health and Family Planning Grant 201640228Shanghai Municipal Commission of Health and Family Planning Grant 20164Y0070Shanghai Municipal Natural Science Foundation 16ZR1428600Shanghai Sailing Program 18YF1420300
6 · The paper itself

Abstract

objectivesThis study explored whether TALENs-mediated non-homologous end joining (NHEJ) targeting the mutation site can correct the aberrant β-globin RNA splicing, and ameliorate the β-thalassaemia phenotype in β MATERIAL AND

methodsTALENs vectors targeted to the human β-globin gene (HBB) IVS2-654C >T mutation in a mouse model were constructed and selected to generate double heterozygous TALENs

resultsSequencing analysis revealed that the HBB IVS2-654C >T point mutation was deleted in over 50% of the TALENs

conclusionThese results suggest effective treatment of the anaemia phenotype in TALENs

Indexed as

Genetic TherapyAnimalsbeta-Globinsbeta-ThalassemiaDisease Models, AnimalGene TargetingMice, TransgenicMutationPhenotypeTranscription Activator-Like Effector Nucleasesbeta-GlobinsTranscription Activator-Like Effector Nucleases

Identifiers

PMID30070404
PMCPMC6528953
OpenAlexW2887716230

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.