Evidence map›Paper›PMID 30070266›Full record

ArticleThe Analyst2018

In vivo detection of drug-induced apoptosis in tumors using Raman spectroscopy.

Oliver Jonas, Jeon Woong Kang, Surya P Singh, Alex Lammers, Freddy T Nguyen, Ramachandra R Dasari, Peter T C So, Robert Langer, Michael J Cima

Open access · hybridAbstract read
In one paragraph

Article in The Analyst, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Oliver JonasDepartment of Radiology, Brigham & Women's Hospital, Boston, MA 02115, USA. ojonas@bwh.harvard.edu.
Jeon Woong Kang
Surya P Singh
Alex Lammers
Freddy T Nguyen
Ramachandra R Dasari
Peter T C So
Robert Langer
Michael J Cima
Laser Research Institute · CNMassachusetts Institute of Technology · USBrigham and Women's Hospital · US

Funding

Wide-Field Short-Wave Infrared (SWIR) multiphoton (MP) tissue imagingP41EB015871 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI SO, PETER T. · 2012 to 2021
$11.3M
Implantable microdevices with integrated optical imaging for high-throughput in situ tumor response and drug sensitivity measurementR37CA224144 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI JONAS, OLIVER · 2018 to 2023
$2.4M
NCI NIH HHS R37 CA224144NIBIB NIH HHS P41 EB015871
6 · The paper itself

Abstract

We describe a label-free approach based on Raman spectroscopy, to study drug-induced apoptosis in vivo. Spectral-shifts at wavenumbers associated with DNA, proteins, lipids, and collagen have been identified on breast and melanoma tumor tissues. These findings may enable a new analytical method for rapid readout of drug-therapy with miniaturized probes.

Indexed as

AnimalsAntibodiesAntineoplastic AgentsApoptosisBreast NeoplasmsCaspase 3DoxorubicinImmunohistochemistryIntercalating AgentsMelanomaMice, NudeSpectrum Analysis, RamanAntibodiesAntineoplastic AgentsCasp3 protein, mouseCaspase 3DoxorubicinIntercalating Agents

Identifiers

PMID30070266
PMCPMC6175619
OpenAlexW2883301176

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.