Evidence map›Paper›PMID 30070262›Full record

ArticleMedical science monitor : international medical journal of experimental and clinical research2018

Baicalein Protects Rats with Diabetic Cardiomyopathy Against Oxidative Stress and Inflammation Injury via Phosphatidylinositol 3-Kinase (PI3K)/AKT Pathway.

Lin Ma, Xiang Peng Li, Heng Sheng Ji, Yue Fen Liu, En Ze Li

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medical science monitor : international medical journal of experimental and clinical research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 49 citations in OpenAlex.

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  17. Meta-analysis Flavonoids from traditional Chinese herbs for diabetes in rats: a network Meta-analysi.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Lin MaDepartment of Pharmacy, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China (mainland).
Xiang Peng LiDepartment of Pharmacy, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China (mainland).
Heng Sheng JiDepartment of Pharmacy, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China (mainland).
Yue Fen LiuDepartment of Pharmacy, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China (mainland).
En Ze LiDepartment of Pharmacy, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China (mainland).
Affiliated Hospital of Qingdao University · CNQingdao University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND The aim of this study was to explore the effect of baicalein on diabetic cardiomyopathy (DCM) rats and the mechanisms involved, and to determine the theoretical basis for clinical anti-tumor therapy. MATERIAL AND METHODS DCM rat model was induced with a single injection of streptozotocin. Then, DCM rats were treated with baicalein alone or co-treated with baicalein and PI3K/Akt inhibitor. Myocardial pathological changes were detected by HE and Masson staining. The activities of SOD, GSH-Px, and MDA in myocardial tissue were measured by biochemical tests. The levels of TNF-α, IL-1β, and cTn-I were examined by ELISA. NADP+/NADPH ratio was measured with the NADP+/NADPH assay kit. RT-PCR was used to detect the levels of PI3K and Akt. The levels of Bax, Bcl-2, Caspase-3, GSK-3β, PI3K, and Akt were detected by Western blot. RESULTS Baicalein could improve pathological injury. SOD and GSH-Px activity decreased while the level of MDA increased in myocardial tissue. Baicalein treatment enhanced SOD activity in a dose-dependent manner but markedly reduced MDA. Similar changes were observed in both serum inflammatory factors and the NADP+/NADPH ratio. After adding PI3K-Akt inhibitor, the levels of PI3K and Akt mRNA expression were significantly decreased, but were not significantly different from the DCM group. Levels of Bcl-2, PI3K, p-GSK-3β/GSK-3β, and p-Akt were decreased in the DCM group, while the levels of Bax and Caspase-3 were obviously increased. CONCLUSIONS Baicalein can protect DCM rats against damage from oxidative stress and inflammation in myocardial tissue, and PI3K/Akt signaling pathway may be involved to mediating these effects.

Indexed as

AnimalsChinaDiabetic CardiomyopathiesDisease Models, AnimalFlavanonesInflammationMaleMyocardial Reperfusion InjuryMyocardiumOxidative StressPhosphatidylinositol 3-KinaseProtective AgentsProto-Oncogene Proteins c-aktRatsRats, Sprague-DawleySignal TransductionbaicaleinFlavanonesPhosphatidylinositol 3-KinaseProtective AgentsProto-Oncogene Proteins c-akt

Identifiers

PMID30070262
PMCPMC6085984
OpenAlexW2886958232

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.