ArticleeLife2018
MDN brain descending neurons coordinately activate backward and inhibit forward locomotion.
Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
50 citing papers in PubMed, 1 synthesis or guideline pooled it, 131 citations in OpenAlex.
- The evolutionary trajectory of drosophilid walking.Current biology : CB · 2022Pooled it
- Complete muscle denervation triggers compensatory sprouting of a bystander tonic motor neuron iniScience · 2026Article
- Mechanisms that create a sequence of feeding-related behaviors in the molluskJournal of neurophysiology · 2026Article
- Cell body clustering drives gap junction-mediated synchronous activity in command neurons.bioRxiv : the preprint server for biology · 2026Article
- Hunchback functions in the postmitotic larval MDN to restrict axon outgrowth, synapse formation, and backward locomotion.Genes & development · 2026Article
- A new system for studying neuronal remodeling and its relation to behavior in Drosophila.Communications biology · 2025Article
- An essential experimental control for functional connectivity mapping with optogenetics.Genetics · 2025Article
- A switch in arousal circuit architecture shapes sleep across the lifespan.bioRxiv : the preprint server for biology · 2025Article
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- Neural substrates of cold nociception ineLife · 2025Article
- Convergent effects of peptides on the initiation of feeding motor programs in the molluskJournal of neurophysiology · 2025Article
- Inhibitory control explains locomotor statistics in walkingProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Inhibitory circuit motifs in Drosophila larvae generate motor program diversity and variability.PLoS biology · 2025Article
- Triggering and modulation of a complex behavior by a single peptidergic command neuron inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- The Hunchback transcription factor determines interneuron molecular identity, morphology, and presynapse targeting in the Drosophila NB5-2 lineage.PLoS biology · 2025Article
- CRASH2p: Closed-loop Two Photon Imaging in a Freely Moving Animal.bioRxiv : the preprint server for biology · 2024Article
- Inhibitory control of locomotor statistics in walkingbioRxiv : the preprint server for biology · 2024Article
- STEERING FROM THE REAR: COORDINATION OF CENTRAL PATTERN GENERATORS UNDERLYING NAVIGATION BY ASCENDING INTERNEURONS.bioRxiv : the preprint server for biology · 2024Article
- A tonically active master neuron modulates mutually exclusive motor states at two timescales.Science advances · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Command-like descending neurons can induce many behaviors, such as backward locomotion, escape, feeding, courtship, egg-laying, or grooming (we define 'command-like neuron' as a neuron whose activation elicits or 'commands' a specific behavior). In most animals, it remains unknown how neural circuits switch between antagonistic behaviors: via top-down activation/inhibition of antagonistic circuits or via reciprocal inhibition between antagonistic circuits. Here, we use genetic screens, intersectional genetics, circuit reconstruction by electron microscopy, and functional optogenetics to identify a bilateral pair of
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.