Trial reporteLife2018
Effects of spinal cord stimulation on postural control in Parkinson's disease patients with freezing of gait.
Trial report in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 28 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Spinal Cord Stimulation on Gait in Patients With Parkinson´s Disease; a Randomized, Crossover, Double Blinded, Placebo-Controlled Study
Effects of Repetitive Trans Spinal Magnetic Stimulation Associated With Treadmill Gait Training on Gait Disorders in Patients With Parkinson's Disease
Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- A Pragmatic Review on Spinal Cord Stimulation Therapy for Parkinson's Disease Gait Related Disorders: Gaps and Controversies.Movement disorders clinical practice · 2024Pooled it
- Spinal Cord Stimulation for Gait Disorders in Parkinson's Disease.Journal of Parkinson's disease · 2023Pooled it
- Spinal Cord Stimulation for Parkinson's Disease: A Systematic Review and Meta-Analysis of Pain and Motor Outcomes.Stereotactic and functional neurosurgery · 2023Pooled it
- Efficacy of Repetitive Trans-spinal Magnetic Stimulation for Patients with Parkinson's Disease: a Randomised Controlled Trial.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022Trial
- Feasibility of Real-Time Autonomous Functional Electrical Stimulation for Freezing of Gait.The European journal of neuroscience · 2026Article
- Harnessing Spinal Cord Stimulation and Neuromodulation for Functional Restoration: From Pain Management to Motor Recovery.Brain sciences · 2026Review
- Effect of cerebrospinal dual-site magnetic stimulation on freezing of gait in Parkinson's disease.NPJ Parkinson's disease · 2024Article
- Clinical neurophysiology in the treatment of movement disorders: IFCN handbook chapter.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024Review
- Spinal cord stimulation for postural abnormalities in Parkinson's disease: 1-year prospective pilot study.BMC neurology · 2024Article
- Mesencephalic Locomotor Region and Presynaptic Inhibition during Anticipatory Postural Adjustments in People with Parkinson's Disease.Brain sciences · 2024Article
- Knowledge mapping of freezing of gait in Parkinson's disease: a bibliometric analysis.Frontiers in neuroscience · 2024Article
- Another Step Forward for Freezing of Gait in Parkinson's Disease.Journal of Parkinson's disease · 2024Article
- Spinal stimulation for unfreezing gait in Parkinson's disease.Nature medicine · 2023Article
- A spinal cord neuroprosthesis for locomotor deficits due to Parkinson's disease.Nature medicine · 2023Article
- High cervical spinal cord stimulation in Parkinson's disease with dopamine-resistant axial disabilities: a case with 2-year follow-up.Journal of neurology · 2023Article
- Gaps and roadmap of novel neuromodulation targets for treatment of gait in Parkinson's disease.NPJ Parkinson's disease · 2022Review
- Spinal cord stimulation therapy for patients with Parkinson's disease and gait problems (STEP-PD): study protocol for an exploratory, double-blind, randomised, placebo-controlled feasibility trial.BMJ neurology open · 2022Article
- Algorithms for Automated Calibration of Transcutaneous Spinal Cord Stimulation to Facilitate Clinical Applications.Journal of clinical medicine · 2021Article
- Freezing of Gait in Parkinson's Disease: Invasive and Noninvasive Neuromodulation.Neuromodulation : journal of the International Neuromodulation Society · 2021Review
- Spinal cord stimulation therapy for gait dysfunction in progressive supranuclear palsy patients.Journal of neurology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
Abstract
Freezing of gait (FoG) in Parkinson's disease (PD) is an incapacitating transient phenomenon, followed by continuous postural disorders. Spinal cord stimulation (SCS) is a promising intervention for FoG in patients with PD, however, its effects on distinct domains of postural control is not well known. The aim of this study is to assess the effects of SCS on FoG and distinct domains of postural control. Four patients with FoG were implanted with SCS systems in the upper thoracic spine. Anticipatory postural adjustment (APA), reactive postural responses, gait and FoG were biomechanically assessed. In general, the results showed that SCS improved FoG and APA. However, SCS failed to improve reactive postural responses. SCS seems to influence cortical motor circuits, involving the supplementary motor area. On the other hand, reactive posture control to external perturbation that mainly relies on neuronal circuitries involving the brainstem and spinal cord, is less influenced by SCS.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.