Evidence map›Paper›PMID 30070087›Full record

ArticleJournal of Zhejiang University. Science. B

Spontaneous activity in medial orbitofrontal cortex correlates with trait anxiety in healthy male adults.

Shao-Wei Xue, Tien-Wen Lee, Yong-Hu Guo

Abstract read
In one paragraph

Article in Journal of Zhejiang University. Science. B. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Shao-Wei XueInstitutes of Psychological Sciences, Hangzhou Normal University, Hangzhou 311121, China.
Tien-Wen LeeInstitutes of Psychological Sciences, Hangzhou Normal University, Hangzhou 311121, China.
Yong-Hu GuoInstitutes of Psychological Sciences, Hangzhou Normal University, Hangzhou 311121, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Medial orbitofrontal cortex (mOFC) abnormalities have been observed in various anxiety disorders. However, the relationship between mOFC activity and anxiety among the healthy population has not been fully examined. Here, we conducted a resting state functional magnetic resonance imaging (R-fMRI) study with 56 healthy male adults from the Nathan Kline Institute/Rockland Sample (NKI-RS) to examine the relationship between the fractional amplitude of low-frequency fluctuation (fALFF) signals and trait anxiety across the whole brain. A Louvain method for module detection based on graph theory was further employed in the automated functional subdivision to explore subregional correlates of trait anxiety. The results showed that trait anxiety was related to fALFF in the mOFC. Additionally, the resting-state functional connectivity (RSFC) between the right subregions of the mOFC and the precuneus was correlated with trait anxiety. These findings provided evidence about the involvement of the mOFC in anxiety processing among the healthy population.

Indexed as

Brain MappingMagnetic Resonance ImagingAdultAgedAged, 80 and overAnxietyBrainHealthy VolunteersHumansImage Processing, Computer-AssistedMaleMiddle AgedPhenotypePrefrontal CortexSurveys and QuestionnairesYoung AdultTrait anxiety; Fractional amplitude of low-frequency fluctuation (fALFF); Medial orbitofrontal cortex; Precuneus; Functional connectivity

Identifiers

PMID30070087
PMCPMC6102183

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.