Evidence map›Paper›PMID 30070052›Full record

ArticlePsycho-oncology2018

Comorbidities are associated with poorer quality of life and functioning and worse symptoms in the 5 years following colorectal cancer surgery: Results from the ColoREctal Well-being (CREW) cohort study.

Amanda Cummings, Chloe Grimmett, Lynn Calman, Mubarak Patel, Natalia Vadimovna Permyakova, Jane Winter, Jessica Corner, Amy Din, Deborah Fenlon, Alison Richardson and 3 more

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In one paragraph

Article in Psycho-oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Non-gastrointestinal symptom burden following colorectal cancer treatment-a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Pooled it
  3. Pooled it
  4. Quality of life in "chronic" cancer survivors: a meta-analysis.Journal of cancer survivorship : research and practice · 2020
    Pooled it
  5. Return to work in elderly population with cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  6. Review
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  8. Correlates of cancer-related fatigue in colorectal cancer patients at the time of diagnosis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
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  19. Prevalence and determinants of depression up to 5 years after colorectal cancer surgery: results from the ColoREctal Wellbeing (CREW) study.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Amanda CummingsMacmillan Survivorship Research Group, Health Sciences, University of Southampton, Southampton, UK.
Chloe GrimmettMacmillan Survivorship Research Group, Health Sciences, University of Southampton, Southampton, UK.
Lynn CalmanMacmillan Survivorship Research Group, Health Sciences, University of Southampton, Southampton, UK.
Mubarak PatelMacmillan Survivorship Research Group, Health Sciences, University of Southampton, Southampton, UK.
Natalia Vadimovna PermyakovaMacmillan Survivorship Research Group, Health Sciences, University of Southampton, Southampton, UK.
Jane WinterMacmillan Survivorship Research Group, Health Sciences, University of Southampton, Southampton, UK.
Jessica CornerExecutive Office, University of Nottingham, Nottingham, UK.
Amy DinMacmillan Survivorship Research Group, Health Sciences, University of Southampton, Southampton, UK.
Deborah FenlonCollege of Health and Human Sciences, Swansea University, Swansea, UK.
Alison RichardsonUniversity Hospital Southampton NHS Foundation Trust, Southampton, UK.
Peter W SmithSocial Statistics and Demography, Social Sciences, University of Southampton, Southampton, UK.
Members of CREW Study Advisory Committee
Claire FosterMacmillan Survivorship Research Group, Health Sciences, University of Southampton, Southampton, UK.ORCID 0000-0002-4703-8378

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveMore people are living with the consequences of cancer and comorbidity. We describe frequencies of comorbidities in a colorectal cancer cohort and associations with health and well-being outcomes up to 5 years following surgery.

methodsProspective cohort study of 872 colorectal cancer patients recruited 2010 to 2012 from 29 UK centres, awaiting curative intent surgery. Questionnaires administered at baseline (pre-surgery), 3, 9, 15, 24 months, and annually up to 5 years. Comorbidities (and whether they limit activities) were self-reported by participants from 3 months. The EORTC QLQ-C30 and QLQ-CR29 assessed global health/quality of life (QoL), symptoms, and functioning. Longitudinal analyses investigated associations between comorbidities and health and well-being outcomes.

resultsAt baseline, the mean age of participants was 68 years, with 60% male and 65% colon cancer. Thirty-two per cent had 1 and 40% had ≥2 comorbidities. The most common comorbidities were high blood pressure (43%), arthritis/rheumatism (32%), and anxiety/depression (18%). Of those with comorbidities, 37% reported at least 1 that limited their daily activities. Reporting any limiting comorbidities was associated with poorer global health/QoL, worse symptoms, and poorer functioning on all domains over 5-year follow-up. Controlling for the most common individual comorbidities, depression/anxiety had the greatest deleterious effect on outcomes.

conclusionsClinical assessment should prioritise patient-reported comorbidities and whether these comorbidities limit daily activities, as important determinants of recovery of QoL, symptoms, and functioning following colorectal cancer. Targeted interventions and support services, including multiprofessional management and tailored assessment and follow-up, may aid recovery of health and well-being in these individuals.

Indexed as

AgedCancer SurvivorsCohort StudiesColorectal NeoplasmsComorbidityDepressionFemaleHumansMaleMiddle AgedProspective StudiesQuality of LifeSocial SupportSocioeconomic FactorsSurveys and QuestionnairesTime Factorscancercolorectal cancercomorbiditieshealth and well-beinglongitudinaloncologyquality of lifesurvivorship

Identifiers

PMID30070052
PMCPMC6221152

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.