Evidence map›Paper›PMID 30070041›Full record

ArticleEuropean journal of heart failure2018

Epicardial fat in heart failure patients with mid-range and preserved ejection fraction.

Gijs van Woerden, Thomas M Gorter, B Daan Westenbrink, Tineke P Willems, Dirk J van Veldhuisen, Michiel Rienstra

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of heart failure, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 156 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
156citing papers in PubMed, 7 pooled it
16.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

156 citing papers in PubMed, 7 syntheses or guidelines pooled it, 262 citations in OpenAlex.

  1. Pooled it
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  6. Highlights in heart failure.ESC heart failure · 2019
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  13. Excess Epicardial Fat and Myocardial Remodeling After Mitral Valve Surgery.Journal of cardiovascular development and disease · 2026
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96 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Gijs van WoerdenDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Thomas M GorterDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
B Daan WestenbrinkDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Tineke P WillemsDepartment of Radiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Dirk J van VeldhuisenDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Michiel RienstraDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
University Medical Center Groningen · NLUniversity of Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsAdipose tissue and inflammation may play a role in the pathophysiology of patients with heart failure (HF) with mildly reduced or preserved ejection fraction. We therefore investigated epicardial fat in patients with HF with preserved (HFpEF) and mid-range ejection fraction (HFmrEF), and related this to co-morbidities, plasma biomarkers and cardiac structure. METHODS AND

resultsA total of 64 HF patients with left ventricular ejection fraction >40% and 20 controls underwent routine cardiac magnetic resonance examination. Epicardial fat volume was quantified on short-axis cine stacks covering the entire epicardium and was related to clinical correlates, biomarkers associated with inflammation and myocardial injury, and cardiac function and contractility on cardiac magnetic resonance. HF patients and controls were of comparable age, sex and body mass index. Total epicardial fat volume was significantly higher in HF patients compared to controls (107 mL/m

conclusionHeart failure patients had more epicardial fat compared to controls, despite similar body mass index. Epicardial fat volume was associated with the presence of atrial fibrillation and type 2 diabetes mellitus and with biomarkers related to myocardial injury. The clinical implications of these findings are unclear, but warrant further investigation.

Indexed as

Adipose TissueAgedBiomarkersEchocardiographyFemaleHeart FailureHumansMagnetic Resonance Imaging, CineMaleNatriuretic Peptide, BrainPeptide FragmentsPericardiumPrognosisStroke VolumeTroponin TVentricular Function, LeftBiomarkersNatriuretic Peptide, BrainPeptide Fragmentspro-brain natriuretic peptide (1-76)Troponin TAtrial fibrillationCardiac magnetic resonance imagingEpicardial fatHeart failure with mid-range ejection fractionHeart failure with preserved ejection fraction

Identifiers

PMID30070041
PMCPMC6607508
OpenAlexW2886821858

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.