ArticleChemistry (Weinheim an der Bergstrasse, Germany)2018
Photochemical "In-Air" Combinatorial Discovery of Antimicrobial Co-polymers.
Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The trial behind it
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Who cites it
14 citing papers in PubMed, 47 citations in OpenAlex.
- AI-guided precise design of antimicrobial polymers through high-throughput screening technology on an automated platform.Bioactive materials · 2026Article
- Gene Delivery Mediated by Backbone-Degradable RAFT Copolymers.Biomacromolecules · 2026Article
- Screening of Hydrophilic Polymers Reveals Broad Activity in Protecting Phages during Cryopreservation.Biomacromolecules · 2024Article
- Anionic Synthetic Polymers Prevent Bacteriophage Infection.Journal of the American Chemical Society · 2023Article
- A fully automated platform for photoinitiated RAFT polymerization.Digital discovery · 2023Article
- Lytic polyplex vaccines enhance antigen-specific cytotoxic T cell response through induction of local cell death.Advanced therapeutics · 2021Article
- Review
- Automation and data-driven design of polymer therapeutics.Advanced drug delivery reviews · 2021Review
- Progress and Perspectives Beyond Traditional RAFT Polymerization.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Review
- Combinatorial Biomaterials Discovery Strategy to Identify New Macromolecular Cryoprotectants.ACS macro letters · 2020Article
- Automation of Controlled/Living Radical Polymerization.Advanced intelligent systems (Weinheim an der Bergstrasse, Germany) · 2020Article
- PET-RAFT and SAXS: High Throughput Tools to Study Compactness and Flexibility of Single-Chain Polymer Nanoparticles.Macromolecules · 2019Article
- High-Throughput Tertiary Amine Deoxygenated Photopolymerizations for Synthesizing Polymer Libraries.Macromolecules · 2019Article
- Photochemical "In-Air" Combinatorial Discovery of Antimicrobial Co-polymers.Chemistry (Weinheim an der Bergstrasse, Germany) · 2018Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
There is an urgent need to identify new, non-traditional antimicrobials. The discovery of new polymeric antimicrobials is limited by current low-throughput synthetic tools, which means that limited chemical space has been explored. Herein, we employ photochemical "in-air" reversible addition-fragmentation chain-transfer (RAFT) polymerization with microwell plates, using liquid-handling robots to assemble large libraries of cationic polymers, without the need for degassing or purification steps, facilitating transfer to screening. Several lead polymers were identified including a co-polymer with propylene glycol side chains with significantly enhanced antimicrobial activity and increased therapeutic window. Mechanistic studies showed that this polymer was bacteriostatic, and surprisingly did not lyse the cell membranes, implying an alternative mode of action. This versatile method using simple robotics will help to develop new biomaterials with emergent properties.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.