ArticleThe Journal of comparative neurology2018
Microglia changes associated to Alzheimer's disease pathology in aged chimpanzees.
Article in The Journal of comparative neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 36 citations in OpenAlex.
- Changes in microglial morphologies during brain aging in common marmosets.Brain structure & function · 2026Article
- Shedding light on microglial dysregulation in Alzheimer's disease: exploring molecular mechanisms and therapeutic avenues.Inflammopharmacology · 2025Review
- Amyloid-Beta, Tau, and Microglial Activation in Aged Felid Brains.The Journal of comparative neurology · 2024Article
- An overview on microglial origin, distribution, and phenotype in Alzheimer's disease.Journal of cellular physiology · 2024Review
- Age differences in cortical thickness and their association with cognition in chimpanzee (Pan troglodytes).Neurobiology of aging · 2023Article
- Evolutionary and genomic perspectives of brain aging and neurodegenerative diseases.Progress in brain research · 2023Article
- Comparative analysis of astrocytes in the prefrontal cortex of primates: Insights into the evolution of human brain energetics.The Journal of comparative neurology · 2022Article
- Exploring the zinc-related transcriptional landscape in Alzheimer's disease.IBRO neuroscience reports · 2022Article
- Different phenotypes of microglia in animal models of Alzheimer disease.Immunity & ageing : I & A · 2022Review
- Article
- Dual-targeted magnetic mesoporous silica nanoparticles reduce brain amyloid-β burden via depolymerization and intestinal metabolism.Theranostics · 2022Article
- Functional and Phenotypic Diversity of Microglia: Implication for Microglia-Based Therapies for Alzheimer's Disease.Frontiers in aging neuroscience · 2022Review
- Age- and cognition-related differences in the gray matter volume of the chimpanzee brain (Pan troglodytes): A voxel-based morphometry and conjunction analysis.American journal of primatology · 2021Article
- Comparative neuropathology in aging primates: A perspective.American journal of primatology · 2021Review
- Integrated phylogeny of the human brain and pathobiology of Alzheimer's disease: A unifying hypothesis.Neuroscience letters · 2021Review
- Review
- Dystrophic microglia are associated with neurodegenerative disease and not healthy aging in the human brain.Neurobiology of aging · 2021Article
- Age-related changes in chimpanzee (Pan troglodytes) cognition: Cross-sectional and longitudinal analyses.American journal of primatology · 2021Article
- An update on the rod microglia variant in experimental and clinical brain injury and disease.Brain communications · 2021Review
- Neuron loss associated with age but not Alzheimer's disease pathology in the chimpanzee brain.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
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Authors and funding
11 authors at 8 institutions in 1 country.
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Abstract
In Alzheimer's disease (AD), the brain's primary immune cells, microglia, become activated and are found in close apposition to amyloid beta (Aβ) protein plaques and neurofibrillary tangles (NFT). The present study evaluated microglia density and morphology in a large group of aged chimpanzees (n = 20, ages 37-62 years) with varying degrees of AD-like pathology. Using immunohistochemical and stereological techniques, we quantified the density of activated microglia and morphological variants (ramified, intermediate, and amoeboid) in postmortem chimpanzee brain samples from prefrontal cortex, middle temporal gyrus, and hippocampus, areas that show a high degree of AD pathology in humans. Microglia measurements were compared to pathological markers of AD in these cases. Activated microglia were consistently present across brain areas. In the hippocampus, CA3 displayed a higher density than CA1. Aβ42 plaque volume was positively correlated with higher microglial activation and with an intermediate morphology in the hippocampus. Aβ42-positive vessel volume was associated with increased hippocampal microglial activation. Activated microglia density and morphology were not associated with age, sex, pretangle density, NFT density, or tau neuritic cluster density. Aged chimpanzees displayed comparable patterns of activated microglia phenotypes as well as an association of increased microglial activation and morphological changes with Aβ deposition similar to AD patients. In contrast to human AD brains, activated microglia density was not significantly correlated with tau lesions. This evidence suggests that the chimpanzee brain may be relatively preserved during normal aging processes but not entirely protected from neurodegeneration as previously assumed.
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