Evidence map›Paper›PMID 30069835›Full record

ReviewCerebellum (London, England)2018

Depressed by Learning-Heterogeneity of the Plasticity Rules at Parallel Fiber Synapses onto Purkinje Cells.

Aparna Suvrathan, Jennifer L Raymond

Abstract readReview
In one paragraph

Review in Cerebellum (London, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Flexible Coupling of Synaptic and Intrinsic Plasticity in a Cerebellar Circuit.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  2. Classical conditioning of Purkinje cell responsesBiochemistry and biophysics reports · 2026
    Article
  3. Purkinje Cell Collaterals Preferentially Target a Subtype of Molecular Layer Interneuron.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  4. Article
  5. Article
  6. Heterogeneity in Slow Synaptic Transmission Diversifies Purkinje Cell Timing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. The Origin of Physiological Local mGluR1 Supralinear CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2020
    Article
  14. Article
  15. Article
  16. Article
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  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Aparna SuvrathanCentre for Research in Neuroscience, Department of Neurology and Neurosurgery, Department of Pediatrics, Brain Repair and Integrative Neuroscience Program, the Research Institute of the McGill University Health Centre, McGill University, Montréal General Hospital, Montréal, Quebec, H3G 1A4, Canada.
Jennifer L RaymondDepartment of Neurobiology, Stanford University, Stanford, CA, 94305, USA. jenr@stanford.edu.

Funding

VESTIBULAR AND VISUAL CONTROL OF EYE MOVEMENTR01DC004154 · NIDCD · STANFORD UNIVERSITY · PI GOLDMAN, MARK S, RAYMOND, JENNIFER L · 1999 to 2025
$9.6M
Instructive Signals for Motor LearningR01NS072406 · NINDS · STANFORD UNIVERSITY · PI Jennifer L Raymond · 2010 to 2026
$7.6M
National Institutes of Health R01 NS072406National Institutes of Health RO1 DC04154NIDCD NIH HHS R01 DC004154NINDS NIH HHS R01 NS072406Simons Collaboration on the Global Brain 543031
6 · The paper itself

Abstract

Climbing fiber-driven long-term depression (LTD) of parallel fiber synapses onto cerebellar Purkinje cells has long been investigated as a putative mechanism of motor learning. We recently discovered that the rules governing the induction of LTD at these synapses vary across different regions of the cerebellum. Here, we discuss the design of LTD induction protocols in light of this heterogeneity in plasticity rules. The analytical advantages of the cerebellum provide an opportunity to develop a deeper understanding of how the specific plasticity rules at synapses support the implementation of learning.

Indexed as

AnimalsLearningMotor ActivityNeuronal PlasticityPurkinje CellsSynapsesAssociative plasticityHeterogeneityLearningLong-term depressionOculomotorPurkinje cellShort-term depressionSynaptic plasticity

Identifiers

PMID30069835
PMCPMC6550343

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.