Evidence map›Paper›PMID 30069831›Full record

ArticleMolecular neurobiology2019

Chronic Dysregulation of Cortical and Subcortical Metabolism After Experimental Traumatic Brain Injury.

Jennifer L McGuire, Erica A K DePasquale, Miki Watanabe, Fatima Anwar, Laura B Ngwenya, Gowtham Atluri, Lindsey E Romick-Rosendale, Robert E McCullumsmith, Nathan K Evanson

Open access · greenAbstract read
In one paragraph

Article in Molecular neurobiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
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  4. Tracing the path of disruption:CNS neuroscience & therapeutics · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Jennifer L McGuireDepartment of Neurosurgery, University of Cincinnati, Cincinnati, OH, 45267, USA. jennifer.mcguire@uc.edu.ORCID http://orcid.org/0000-0003-3058-5241
Erica A K DePasqualeGraduate Program in Biomedical Informatics, University of Cincinnati, Cincinnati, OH, 45267, USA.
Miki WatanabeDivision of Pathology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA.
Fatima AnwarDepartment of Neurosurgery, University of Cincinnati, Cincinnati, OH, 45267, USA.
Laura B NgwenyaDepartment of Neurosurgery, University of Cincinnati, Cincinnati, OH, 45267, USA.
Gowtham AtluriGraduate Program in Biomedical Informatics, University of Cincinnati, Cincinnati, OH, 45267, USA.
Lindsey E Romick-RosendaleDivision of Pathology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA.
Robert E McCullumsmithDepartment of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati, OH, 45267, USA.
Nathan K EvansonDepartment of Pediatrics, University of Cincinnati, Cincinnati, OH, 45267, USA.
University of Cincinnati · USCincinnati Children's Hospital Medical Center · US

Funding

Cell-specific analysis of sub-kinomes in schizophreniaR01MH107487 · NIMH · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI MCCULLUMSMITH, ROBERT E, MELLER, JAREK · 2016 to 2020
$1.9M
Proteomic analysis of the postsynaptic density-95 interactome in schizophreniaR21MH107916 · NIMH · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI MCCULLUMSMITH, ROBERT E · 2016 to 2017
$434k
Cincinnati Children's Hospital Medical Center Shared Facilities Discovery AwardNIMH NIH HHS R01 MH107487NIMH NIH HHS R21 MH107916
6 · The paper itself

Abstract

Traumatic brain injury (TBI) is a leading cause of death and long-term disability worldwide. Although chronic disability is common after TBI, effective treatments remain elusive and chronic TBI pathophysiology is not well understood. Early after TBI, brain metabolism is disrupted due to unregulated ion release, mitochondrial damage, and interruption of molecular trafficking. This metabolic disruption causes at least part of the TBI pathology. However, it is not clear how persistent or pervasive metabolic injury is at later stages of injury. Using untargeted

Indexed as

AnimalsBrain Injuries, TraumaticCerebral CortexChronic DiseaseMaleMetabolic Networks and PathwaysMetabolomeRats, Sprague-DawleyChronic TBICorrelations-based analysisLateral fluid percussionNetwork structureNMR metabolomics

Identifiers

PMID30069831
PMCPMC7584385
OpenAlexW2887397955

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.