Evidence map›Paper›PMID 30069789›Full record

ArticleEJNMMI research2018

The tetraamine chelator outperforms HYNIC in a new technetium-99m-labelled somatostatin receptor 2 antagonist.

Keelara Abiraj, Samer Ursillo, Maria Luisa Tamma, Svetlana N Rylova, Beatrice Waser, Edwin C Constable, Melpomeni Fani, Guillaume P Nicolas, Jean Claude Reubi, Helmut R Maecke

Open access · goldAbstract read
In one paragraph

Article in EJNMMI research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Development of thePharmaceutics · 2023
    Article
  4. Article
  5. Optimization of the Pharmacokinetic Profile of [Pharmaceuticals (Basel, Switzerland) · 2022
    Article
  6. Review
  7. Review
  8. SPECT Imaging of SST2-Expressing Tumors withPharmaceuticals (Basel, Switzerland) · 2021
    Article
  9. Review
  10. Selection of the FirstPharmaceuticals (Basel, Switzerland) · 2020
    Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Keelara AbirajDivisions of Radiopharmaceutical Chemistry and Nuclear Medicine, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland.
Samer UrsilloDivisions of Radiopharmaceutical Chemistry and Nuclear Medicine, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland.
Maria Luisa TammaDivisions of Radiopharmaceutical Chemistry and Nuclear Medicine, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland.
Svetlana N RylovaDepartment of Nuclear Medicine, Medical Centre - University of Freiburg, Faculty of Medicine, University of Freiburg, Hugstetter Strasse 55, 79106, Freiburg, Germany.
Beatrice WaserDivision of Cell Biology and Experimental Cancer Research, Institute of Pathology, University of Bern, PO Box 62, Murtenstrasse 31, 3010, Bern, Switzerland.
Edwin C ConstableDepartment of Chemistry, University of Basel, Spitalstrasse 51, 4056, Basel, Switzerland.
Melpomeni FaniDivisions of Radiopharmaceutical Chemistry and Nuclear Medicine, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland.
Guillaume P NicolasDivisions of Radiopharmaceutical Chemistry and Nuclear Medicine, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland.
Jean Claude ReubiDivision of Cell Biology and Experimental Cancer Research, Institute of Pathology, University of Bern, PO Box 62, Murtenstrasse 31, 3010, Bern, Switzerland.
Helmut R MaeckeDivisions of Radiopharmaceutical Chemistry and Nuclear Medicine, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland. helmut.maecke@uniklinik-freiburg.de.
University Hospital of Basel · CHUniversity of Bern · CHRoche (Switzerland) · CHUniversity of Basel · CHUniversity of Freiburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSomatostatin receptor targeting radiopeptides are successfully being used to image, stage, and monitor patients with neuroendocrine tumours. They are exclusively agonists that internalise upon binding to the relevant receptor. According to recent reports, antagonists may be preferable to agonists. To date,

resultsThe conjugates showed low nanomolar sst2 affinity and antagonistic properties.

conclusionsThese data indicate a very promising

Indexed as

99mTcNETsSomatostatin receptor antagonistsSPECT/CT

Identifiers

PMID30069789
PMCPMC6070450
OpenAlexW2887389533

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.