ArticleCellular and molecular life sciences : CMLS2018
Defining the role of post-synaptic α-neurotoxins in paralysis due to snake envenoming in humans.
Article in Cellular and molecular life sciences : CMLS, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 54 citations in OpenAlex.
- Antigenic divergence of cobra short-chain α-neurotoxins: Implications for regional antivenom effectiveness in Southeast Asia.PLoS neglected tropical diseases · 2026Article
- Neurotoxicity of Sri Lankan Krait (Toxins · 2025Article
- The Venom Proteome of the Ecologically Divergent Australian Elapid, Southern Death AdderToxins · 2025Article
- Red-on-Yellow Queen: Bio-Layer Interferometry Reveals Functional Diversity Within Micrurus Venoms and Toxin Resistance in Prey Species.Journal of molecular evolution · 2024Article
- Venom diversity in Naja mossambica: Insights from proteomic and immunochemical analyses reveal intraspecific differences.PLoS neglected tropical diseases · 2024Article
- Acetylcholine-Binding Protein Affinity Profiling of Neurotoxins in Snake Venoms with Parallel Toxin Identification.International journal of molecular sciences · 2023Article
- An in vitro assay to investigate venom neurotoxin activity on muscle-type nicotinic acetylcholine receptor activation and for the discovery of toxin-inhibitory molecules.Biochemical pharmacology · 2023Article
- Metabolomics analyses of serum metabolites perturbations associated with Naja atra bite.PLoS neglected tropical diseases · 2023Article
- Equatorial Spitting Cobra (Toxins · 2022Article
- In Vitro Toxicity of Chinese Russell's Viper (Toxins · 2022Article
- Preclinical efficacy testing of three antivenoms againstToxicon: X · 2022Article
- Article
- The Effect of Australian and Asian Commercial Antivenoms in Reversing the Post-Synaptic Neurotoxicity ofToxins · 2022Article
- Review
- Article
- Isolation and Characterization of Two Postsynaptic Neurotoxins From Indian Cobra (Frontiers in pharmacology · 2022Article
- Rodent Lethality Models Are Problematic for Evaluating Antivenoms for Human Envenoming.Frontiers in pharmacology · 2022Article
- Isolation and Pharmacological Characterization of α-Elapitoxin-Oh3a, a Long-Chain Post-Synaptic Neurotoxin From King Cobra (Frontiers in pharmacology · 2022Article
- Monkeying around with venom: an increased resistance to α-neurotoxins supports an evolutionary arms race between Afro-Asian primates and sympatric cobras.BMC biology · 2021Article
- Article
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
Abstract
Snake venom α-neurotoxins potently inhibit rodent nicotinic acetylcholine receptors (nAChRs), but their activity on human receptors and their role in human paralysis from snakebite remain unclear. We demonstrate that two short-chain α-neurotoxins (SαNTx) functionally inhibit human muscle-type nAChR, but are markedly more reversible than against rat receptors. In contrast, two long-chain α-neurotoxins (LαNTx) show no species differences in potency or reversibility. Mutant studies identified two key residues accounting for this. Proteomic and clinical data suggest that paralysis in human snakebites is not associated with SαNTx, but with LαNTx, such as in cobras. Neuromuscular blockade produced by both subclasses of α-neurotoxins was reversed by antivenom in rat nerve-muscle preparations, supporting its effectiveness in human post-synaptic paralysis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.