Evidence map›Paper›PMID 30069674›Full record

ArticleMedical & biological engineering & computing2019

Genetic algorithm based cancerous gene identification from microarray data using ensemble of filter methods.

Manosij Ghosh, Sukdev Adhikary, Kushal Kanti Ghosh, Aritra Sardar, Shemim Begum, Ram Sarkar

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Article in Medical & biological engineering & computing, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

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  17. A weighted ensemble-based active learning model to label microarray data.Medical & biological engineering & computing · 2020
    Article
  18. A two-stage approach towards protein secondary structure classification.Medical & biological engineering & computing · 2020
    Article
  19. Review
4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Manosij GhoshDepartment of Computer Science and Engineering, Jadavpur University, Kolkata, India. manosij1996@gmail.com.ORCID http://orcid.org/0000-0003-2954-9876
Sukdev AdhikaryDepartment of Computer Science and Engineering, Jadavpur University, Kolkata, India.
Kushal Kanti GhoshDepartment of Computer Science and Engineering, Jadavpur University, Kolkata, India.
Aritra SardarDepartment of Computer Science and Engineering, Jadavpur University, Kolkata, India.
Shemim BegumDepartment of Computer Science and Engineering, Government College of Engineering & Textile Technology, Berhampore, West Bengal, India.
Ram SarkarDepartment of Computer Science and Engineering, Jadavpur University, Kolkata, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microarray datasets play a crucial role in cancer detection. But the high dimension of these datasets makes the classification challenging due to the presence of many irrelevant and redundant features. Hence, feature selection becomes irreplaceable in this field because of its ability to remove the unrequired features from the system. As the task of selecting the optimal number of features is an NP-hard problem, hence, some meta-heuristic search technique helps to cope up with this problem. In this paper, we propose a 2-stage model for feature selection in microarray datasets. The ranking of the genes for the different filter methods are quite diverse and effectiveness of rankings is datasets dependent. First, we develop an ensemble of filter methods by considering the union and intersection of the top-n features of ReliefF, chi-square, and symmetrical uncertainty. This ensemble allows us to combine all the information of the three rankings together in a subset. In the next stage, we use genetic algorithm (GA) on the union and intersection to get the fine-tuned results, and union performs better than the latter. Our model has been shown to be classifier independent through the use of three classifiers-multi-layer perceptron (MLP), support vector machine (SVM), and K-nearest neighbor (K-NN). We have tested our model on five cancer datasets-colon, lung, leukemia, SRBCT, and prostate. Experimental results illustrate the superiority of our model in comparison to state-of-the-art methods. Graphical abstract ᅟ.

Indexed as

AlgorithmsGenes, NeoplasmDatabases as TopicGene OntologyHumansNeoplasmsOligonucleotide Array Sequence AnalysisCancer detectionEnsembleFilter methodMicroarray dataWrapper method

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.