Evidence map›Paper›PMID 30069639›Full record

ArticleSurgical endoscopy2019

Laparoscopic combined resection of liver metastases and colorectal cancer: a multicenter, case-matched study using propensity scores.

M J van der Poel, P J Tanis, H A Marsman, A M Rijken, E C Gertsen, S Ovaere, M F Gerhards, M G Besselink, M D'Hondt, P D Gobardhan

Registry-linked trialOpen access · hybridAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Surgical endoscopy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05138094 (LIVACOR Trial), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05138094 naunknown statusnot on this mapstarted 2021, after this paper: background citation

LIVACOR Trial: Minimally Invasive LIVer And Simultaneous COlorectal Resection

TypeinterventionalSponsorFondazione Poliambulanza Istituto OspedalieroRan2021 to 2024Enrolled82ConditionsColorectal Neoplasms Malignant, Neoplasm MetastasisArmsMinimally invasive simultaneous resection, Minimally invasive two-stage resection
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

M J van der PoelDepartment of Surgery, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
P J TanisDepartment of Surgery, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
H A MarsmanDepartment of Surgery, OLVG, Amsterdam, The Netherlands.
A M RijkenDepartment of Surgery, Amphia Hospital, Breda, The Netherlands.
E C GertsenDepartment of Surgery, OLVG, Amsterdam, The Netherlands.
S OvaereDepartment of Digestive and Hepatobiliary/Pancreatic Surgery, Groeninge Hospital, Kortrijk, Belgium.
M F GerhardsDepartment of Surgery, OLVG, Amsterdam, The Netherlands.
M G Besselink *Department of Surgery, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands. m.g.besselink@amc.nl.
M D'Hondt *Department of Digestive and Hepatobiliary/Pancreatic Surgery, Groeninge Hospital, Kortrijk, Belgium.
P D Gobardhan *Department of Surgery, Amphia Hospital, Breda, The Netherlands.
OLVG · NLAmphia Ziekenhuis · NLAZ Groeninge · BEUniversity of Amsterdam · NLAmsterdam University Medical Centers · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCombined laparoscopic resection of liver metastases and colorectal cancer (LLCR) may hold benefits for selected patients but could increase complication rates. Previous studies have compared LLCR with liver resection alone. Propensity score-matched studies comparing LLCR with laparoscopic colorectal cancer resection (LCR) alone have not been performed.

methodsA multicenter, case-matched study was performed comparing LLCR (2009-2016, 4 centers) with LCR alone (2009-2016, 2 centers). Patients were matched based on propensity scores in a 1:1 ratio. Propensity scores were calculated with the following preoperative variables: age, sex, ASA grade, neoadjuvant radiotherapy, type of colorectal resection and T and N stage of the primary tumor. Outcomes were compared using paired tests.

resultsOut of 1020 LCR and 64 LLCR procedures, 122 (2 × 61) patients could be matched. All 61 laparoscopic liver resections were minor hepatectomies, mostly because of a solitary liver metastasis (n = 44, 69%) of small size (≤ 3 cm) (n = 50, 78%). LLCR was associated with a modest increase in operative time [206 (166-308) vs. 197 (148-231) min, p = 0.057] and blood loss [200 (100-700) vs. 75 (5-200) ml, p = 0.011]. The rate of Clavien-Dindo grade 3 or higher complications [9 (15%) vs. 13 (21%), p = 0.418], anastomotic leakage [5 (8%) vs. 4 (7%), p = 1.0], conversion rate [3 (5%) vs. 5 (8%), p = 0.687] and 30-day mortality [0 vs. 1 (2%), p = 1.0] did not differ between LLCR and LCR.

conclusionIn selected patients requiring minor hepatectomy, LLCR can be safely performed without increasing the risk of postoperative morbidity compared to LCR alone.

Indexed as

AgedColorectal NeoplasmsConversion to Open SurgeryFemaleHepatectomyHospital MortalityHumansLaparoscopyLiver NeoplasmsMaleMatched-Pair AnalysisMiddle AgedNeoplasm StagingOperative TimePostoperative ComplicationsPropensity ScoreColorectal liver metastasesColorectal resectionLaparoscopyLiver resectionSimultaneous

Identifiers

PMID30069639
PMCPMC6430752
OpenAlexW2886166558

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.