ReviewSkeletal radiology2019
Instability and impending instability in patients with vertebral metastatic disease.
Review in Skeletal radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- Metastatic Spine Disease Alters Vertebral Load-To-Strength Ratios in Cancer Patients Compared to Healthy Individuals.JOR spine · 2026Article
- A systematic review on frailty indices utilized in oncologic surgery and radiotherapy for metastatic spine disease: A critical appraisal of components and performance.North American Spine Society journal · 2025Review
- Benign or aggressive? Understanding spinal melanocytomas in comparison to malignant melanoma.Journal of neuro-oncology · 2025Article
- Role of Denosumab in Patients with Intermediate Spinal Instability Neoplastic Score (SINS).Cancers · 2025Article
- Surgical options for metastatic spine tumors: WFNS spine committee recommendations.Neurosurgical review · 2024Review
- The Spinal Instability Neoplastic Score correlates with epidural spinal cord compression -a retrospective cohort of 256 surgically treated patients with spinal metastases.BMC musculoskeletal disorders · 2024Article
- Vertebral Primary Bone Lesions: Review of Management Options.Current oncology (Toronto, Ont.) · 2023Review
- Treatment of Metastatic Spinal Disease; what the Radiologist needs to know.The British journal of radiology · 2022Review
- Current Overview of Treatment for Metastatic Bone Disease.Current oncology (Toronto, Ont.) · 2021Review
- Treatment Strategy for Impending Instability in Spinal Metastases.Clinics in orthopedic surgery · 2020Article
- Mechanical Cavity Creation with Curettage and Vacuum Suction (Q-VAC) in Lytic Vertebral Body Lesions with Posterior Wall Dehiscence and Epidural Mass before Cement Augmentation.Medicina (Kaunas, Lithuania) · 2019Article
- Solitary plasmacytoma of thoracic vertebra in a woman with Lynch syndrome: A case report.International journal of surgery case reports · 2019Article
- Changes in Spinal Instability After Conventional Radiotherapy for Painful Vertebral Bone Metastases.Cancer control : journal of the Moffitt Cancer CenterArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metastatic disease commonly involves the spine with an increasing incidence due to a worldwide rise of cancer incidence and a longer survival of patients with osseous metastases. Metastases compromise the mechanical integrity of the vertebra and make it susceptible to fracture. Patients with pathological vertebral fracture often become symptomatic, with mechanical pain generally due to intervertebral instability, and may develop spinal cord compression and neurological deficits. Advances in imaging, radiotherapy, as well as in spinal surgery techniques, have allowed the evolution from conventional palliative external beam radiotherapy to modern stereotactic radiosurgery and from traditional open surgery to less-invasive, and sometimes prophylactic stabilization surgical treatments. It is therefore clear that fracture risk prediction, and maintenance or restoration of intervertebral stability, are important objectives in the management of these patients. Correlation between imaging findings and clinical manifestations is crucial, and a common knowledge base for treatment team members rather than a compartmentalized view is very important. This article reviews the literature on the imaging and clinical diagnosis of intervertebral instability and impending instability in the setting of spine metastatic disease, including the spinal instability neoplastic score, which is a reliable tool for diagnosing unstable or potentially unstable metastatic spinal lesions, and on the different elements considered for treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.