Evidence map›Paper›PMID 30069580›Full record

ReviewWorld journal of urology2019

Update of the International Consultation on Urological Diseases on bladder cancer 2018: non-urothelial cancers of the urinary bladder.

Shaheen Alanee, Isabel Alvarado-Cabrero, Paari Murugan, Rajeev Kumar, Kenneth G Nepple, Gladell P Paner, Manish I Patel, Maria Rosaria Raspollini, Antonio Lopez-Beltran, Badrinath R Konety

Abstract readReview
PubMed Publisher
In one paragraph

Review in World journal of urology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 2 pooled it
8.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 72 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 9 institutions in 6 countries.

Shaheen AlaneeUrologic Oncology, Department of Urology, Vattikuti Urology Institute, Henry Ford Health System, Detroit, MI, USA. brkonety@umn.edu.
Isabel Alvarado-CabreroDepartment of Pathology, Mexican Oncology Hospital, IMSS, CMN SXXI, Mexico City, Mexico.
Paari MuruganDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.
Rajeev KumarAll India Institute of Medical Sciences, New Delhi, India.
Kenneth G NeppleDepartment of Urology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.
Gladell P PanerDepartments of Pathology and Surgery (Urology), University of Chicago, Chicago, IL, USA.
Manish I PatelDepartment of Urology, Westmead Hospital and Discipline of Surgery, University of Sydney, Sydney, Australia.
Maria Rosaria RaspolliniHistopathology and Molecular Diagnostics, University Hospital Careggi, Florence, Italy.
Antonio Lopez-BeltranUniversity of Cordoba, Córdoba, Spain.
Badrinath R KonetyDepartment of Urologic Surgery, University of Minnesota, Minneapolis, MN, USA.
University of Minnesota · USAll India Institute of Medical Sciences · INAzienda Ospedaliero-Universitaria Careggi · ITHenry Ford Health System · USMexican Social Security Institute · MXUniversity of Chicago · USUniversity of Córdoba · ESUniversity of Iowa Hospitals and Clinics · USWestmead Hospital · AU

Funding

Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Douglas Robert Spitz · 2000 to 2026
$70.0M
6 · The paper itself

Abstract

purposeTo provide a comprehensive update of the joint consultation of the International Consultation on Urological Diseases (ICUD) for the diagnosis and management of non-urothelial cancer of the urinary bladder.

methodsA detailed analysis of the literature was conducted reporting on the epidemiology, etiology, diagnosis, treatment and outcomes of non-urothelial cancer of the urinary bladder. An international, multidisciplinary expert committee evaluated and graded the evidence according to the Oxford System of Evidence-based Medicine modified by the ICUD.

resultsThe major non-urothelial cancers of the urinary bladder are squamous cell carcinoma, adenocarcinoma, and neuroendocrine tumors. Several other non-urothelial tumors are rare but important to identify because of their aggressive behavior when compared to urothelial bladder tumors. Radical cystectomy and urinary diversion, preceded by neoadjuvant radiation or chemotherapy in some of these tumors, is the main method or treatment for resectable disease. Adjuvant therapy is not usually successful and no novel targeted or immunotherapeutic agents have been identified to provide benefit. Patients with small cell neuroendocrine tumors of the bladder should be offered chemotherapy before surgery. Because non-urothelial cancers are usually locally advanced and/or metastatic at the time of diagnosis, 5-year survival is generally poor.

conclusionsNon-urothelial cancers of the urinary bladder are rare and mostly lack established protocols for treatment. The prognosis of most of these tumors is poor because they are usually advanced at the time of diagnosis. A multimodal treatment approach should be considered to improve outcomes.

Indexed as

AdenocarcinomaAntineoplastic AgentsCarcinoma, Squamous CellChemotherapy, AdjuvantCystectomyHumansNeoadjuvant TherapyNeuroendocrine TumorsPrognosisRadiotherapyUrinary Bladder NeoplasmsUrinary DiversionAntineoplastic AgentsBladder cancerICUDNon-urothelialUpdate

Identifiers

PMID30069580
OpenAlexW2887910828

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.