ArticleJournal of spine surgery (Hong Kong)2018
Hypothyroidism increases 90-day postoperative complications in patients undergoing primary single level anterior cervical disectomy and fusion: a matched control analysis.
Article in Journal of spine surgery (Hong Kong), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 24 citations in OpenAlex.
- Migraines as a Risk Factor for Many 90-Day Postoperative Complications Following Single-Level Anterior Cervical Diskectomy and Fusion.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2025Article
- Preoperative Anxiety: An Important Risk Factor of Postoperative Adverse Events and Increased Reoperation Rates in Patients Undergoing Single-Level Anterior Cervical Diskectomy and Fusion.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2024Article
- Causal relationship between hypothyroidism and peripheral neuropathy: a Mendelian randomization study of European ancestry.Frontiers in endocrinology · 2024Article
- Hypothyroidism and Spine Surgery: a Review of Current Findings.Current reviews in musculoskeletal medicine · 2023Review
- A nationwide analysis on the effects of chronic obstructive pulmonary disease following primary total shoulder arthroplasty for glenohumeral osteoarthritis.Shoulder & elbow · 2022Article
- Factors associated with post-operative delirium in hip fracture patients: what should we care.European journal of medical research · 2022Article
- Incidence and Clinical Outcomes of Hypothyroidism in Patients Undergoing Spinal Fusion.Cureus · 2021Article
- Article
- High Altitude Is an Independent Risk Factor for Developing a Pulmonary Embolism, but Not a Deep Vein Thrombosis Following a 1- to 2-Level Lumbar Fusion.Global spine journal · 2019Article
- Perioperative complications in patients with sleep apnea following primary total shoulder arthroplasty: An analysis of 33,366 patients.Journal of orthopaedicsArticle
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Authors and funding
6 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAnterior cervical discectomy and fusion (ACDF) is indicated for patients suffering from cervical radiculopathy, myelopathy, and degenerative disc disease, among other diseases. There is paucity in the literature regarding postoperative complications in patients undergoing primary ACDF with a diagnosis of hypothyroidism. The purpose of this study is to compare 90-day postoperative complications in patients with and without hypothyroidism undergoing primary ACDF.
methodsA retrospective analysis was completed using a national administrative database known as Pearl Diver (Pearl Diver Technologies, Fort Wayne, Indiana) using the International Classification of Disease, ninth revision (ICD-9) codes. The study group consisted of patients having undergone ACDF with an active diagnosis of hypothyroidism 90 days prior to and on the day of surgery. Patients undergoing primary ACDF without hypothyroidism served as the control group. Patients in both groups were randomly matched according to age, gender, and Charlson-Comorbidity Index (CCI). The 90-day postoperative medical complications were assessed along with readmission rates and total cost of care.
resultsThere were a total of 107,066 patients equally divided between the 2 cohorts. Patients with hypothyroidism had greater odds of developing complications such as non-healing surgical wound (OR: 2.27; P<0.001), pulmonary embolus (OR: 2.16; P<0.001), myocardial infarction (OR: 2.10; P<0.001), compared to patients in the control group after undergoing primary ACDF. Readmission rates were also higher in patients with hypothyroidism (OR: 1.45; P<0.001). Total cost of care was also greater in patients with hypothyroidism compared to patients without hypothyroidism undergoing primary ACDF.
conclusionsHypothyroidism is a risk factor for worse postoperative outcomes in patients undergoing primary ACDF. Appropriate preoperative optimization with thyroid hormone supplementation could potentially minimize the incidence of developing numerous medical complications, in addition to potentially lowering readmission rates and the total cost of care.
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