Evidence map›Paper›PMID 30069422›Full record

ReviewPediatric allergy, immunology, and pulmonology2018

Asthma Endotyping and Biomarkers in Childhood Asthma.

Amelia Licari, Riccardo Castagnoli, Ilaria Brambilla, Alessia Marseglia, Maria Angela Tosca, Gian Luigi Marseglia, Giorgio Ciprandi

Abstract readReview
In one paragraph

Review in Pediatric allergy, immunology, and pulmonology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

74 citing papers in PubMed.

  1. Article
  2. Review
  3. Asthma: onset at young, persist when grow up.Translational pediatrics · 2026
    Review
  4. Article
  5. Review
  6. Updated therapeutics of asthma.World journal of pediatrics : WJP · 2025
    Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Effects of Family-Supported Healthcare on Children with Asthma.Therapeutics and clinical risk management · 2024
    Article
  14. Unanswered questions on the use of biologics in pediatric asthma.The World Allergy Organization journal · 2023
    Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. Diagnostic value of IL-6 for patients with asthma: a meta-analysis.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2023
    Review
  20. Article

14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Amelia LicariPediatric Clinic, Fondazione IRCCS San Matteo, Pavia, Italy.
Riccardo CastagnoliPediatric Clinic, Fondazione IRCCS San Matteo, Pavia, Italy.
Ilaria BrambillaPediatric Clinic, Fondazione IRCCS San Matteo, Pavia, Italy.
Alessia MarsegliaPediatric Clinic, Fondazione IRCCS San Matteo, Pavia, Italy.
Maria Angela ToscaPediatric Allergy, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Gian Luigi MarsegliaPediatric Clinic, Fondazione IRCCS San Matteo, Pavia, Italy.
Giorgio CiprandiIRCCS Ospedale Policlinico San Martino, Genoa, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Childhood asthma represents a heterogeneous challenging disease, in particular in its severe forms. The identification of different asthma phenotypes has stimulated research in underlying molecular mechanisms, such as the endotypes, and paved the way to the search for related specific biomarkers, which may guide diagnosis, management, and predict response to treatment. A limited number of biomarkers are currently available in clinical practice in the pediatric population, mostly reflecting type 2-high airway inflammation. The identification of biomarkers of childhood asthma is an active area of research that holds a potential great clinical utility and may represent a step forward toward tailored management and therapy: the so-called Precision Medicine. The aim of the present review is to provide an updated overview of asthma endotyping, mostly focusing on novel noninvasive biomarkers in childhood asthma.

Indexed as

airway inflammationasthmabiomarkerschildreneosinophilsexhaled nitric oxideIgE

Identifiers

PMID30069422
PMCPMC6069590

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.