ArticleJournal of thoracic disease2018
Extended resections of large thymomas: importance of
Article in Journal of thoracic disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Applying expertise: Extrapleural pneumonectomy and extended pleurectomy decortication in the management of Masaoka-Koga stage IV thymoma.JTCVS open · 2025Article
- The clinical significance of open vs. minimally invasive surgical approaches in the management of thymic epithelial tumors and myasthenia gravis.Frontiers in surgery · 2024Review
- Giant thymoma with complete superior vena cava obstruction.Indian journal of thoracic and cardiovascular surgery · 2023Article
- Thymic tumours: a single center surgical experience and literature review on the current diagnosis and management of thymic malignancies.Gland surgery · 2021Review
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Authors and funding
7 authors.
Funding
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Abstract
backgroundPrimary tumors of the thymus are rare; the most common histologic type is thymoma. Most important prognostic factors are anatomical extent of tumor and completeness of surgical resection. Large size has not been directly associated with survival, but is strongly associated with advanced disease and high rates of incomplete resections.
methodsA retrospective cohort of patients who underwent thymectomy for thymomas of 5 cm or larger at the National Cancer Institute (INCan) of México from January 2005 to December 2016 was analyzed. Primary end-points were rate of complete resection, morbidity and mortality of thymectomy. Secondary end-points were overall survival (OS) and disease-free survival (DFS).
resultsA total of 25 patients were identified and included in the final analysis. Mean age was 56.6 years (27-82 years). Median size of thymoma was 8.3 cm (5-14 cm). Transesternal approach was used in 72% of cases, most of cases (68%) required an extended resection to achieve negative margins. Complete resection was achieved on 23 cases (92%). A 90-day morbidity of 24% and mortality of 8% was found, with a median follow-up of 34.5 months (1-113 months). The only factor associated with OS was completeness of surgical resection (P<0.0001).
conclusionsSize of thymomas should not be considered as a contraindication for surgical treatment. Our data suggest that extended surgery is feasible even in advanced cases and provides the best chance for cure. Complete resection remains as one of the most important prognostic factor in thymomas and is associated with prolonged DFS and OS.
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