Evidence map›Paper›PMID 30069221›Full record

ArticleEvidence-based complementary and alternative medicine : eCAM2018

Probiotic Cell-Free Supernatants Exhibited Anti-Inflammatory and Antioxidant Activity on Human Gut Epithelial Cells and Macrophages Stimulated with LPS.

Stefania De Marco, Marzia Sichetti, Diana Muradyan, Miranda Piccioni, Giovanna Traina, Rita Pagiotti, Donatella Pietrella

Abstract read
In one paragraph

Article in Evidence-based complementary and alternative medicine : eCAM, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 141 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
141citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

141 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Effect of Heat-TreatedNutrients · 2024
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  9. Barrier and Immune Modulation byInternational journal of molecular sciences · 2026
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81 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Stefania De MarcoUnit of Biochemical Sciences and Health, Department of Pharmaceutical Sciences, University of Perugia, Via del Giochetto, 06122 Perugia, Italy.
Marzia SichettiUnit of Biochemical Sciences and Health, Department of Pharmaceutical Sciences, University of Perugia, Via del Giochetto, 06122 Perugia, Italy.
Diana MuradyanDepartment of Medical Microbiology, Yerevan State Medical University after Mkhitar Heratsi, 2 Koryun Str., 375025 Yerevan, Armenia.
Miranda PiccioniUnit of Biochemical Sciences and Health, Department of Pharmaceutical Sciences, University of Perugia, Via del Giochetto, 06122 Perugia, Italy.
Giovanna TrainaUnit of Food and Nutritional Sciences, Department of Pharmaceutical Sciences, University of Perugia, Perugia, Italy.
Rita PagiottiUnit of Biochemical Sciences and Health, Department of Pharmaceutical Sciences, University of Perugia, Via del Giochetto, 06122 Perugia, Italy.
Donatella PietrellaUnit of Biochemical Sciences and Health, Department of Pharmaceutical Sciences, University of Perugia, Via del Giochetto, 06122 Perugia, Italy.ORCID 0000-0003-1572-4290

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The incidence of inflammatory bowel disease is increasing all over the world, especially in industrialized countries. The aim of the present work was to verify the anti-inflammatory activity of metabolites. In particular, cell-free supernatants of

Identifiers

PMID30069221
PMCPMC6057331

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.