Evidence map›Paper›PMID 30069205›Full record

ArticleIranian journal of parasitology

Immunogenicity of Multiepitope Vaccine Candidate against

Khalid Hajissa, Robaiza Zakaria, Rapeah Suppian, Zeehaida Mohamed

Open access · greenAbstract read
In one paragraph

Article in Iranian journal of parasitology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.0field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

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  10. A Review on the Prevalence ofInternational journal of environmental research and public health · 2020
    Review
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  12. Epitope-based vaccine as a universal vaccination strategy againstJournal of advanced veterinary and animal research · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Khalid HajissaDept. of Zoology, Faculty of Science and Technology, Omdurman Islamic University, Omdurman, Sudan.
Robaiza ZakariaDept. of Medical Microbiology & Parasitology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Ku-bang Kerian, Kelantan, Malaysia.
Rapeah SuppianBiomedicine Program, School of Health Sciences, Universiti Sains Malaysia, 16150 Kuban Kerian, Kelantan, Malaysia.
Zeehaida MohamedDept. of Medical Microbiology & Parasitology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Ku-bang Kerian, Kelantan, Malaysia.
Universiti Sains Malaysia · MYOmdurman Islamic University · SD

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background

methodsMice were immunized subcutaneously with three doses of USM.TOXO1 antigen (10 μg/ml). Following the immunization, the IgG antibody, IgG subclass, IFN-γ and IL-4 production were evaluated using ELISA, the study was conducted at Animal Research and Service Center (ARASC), USM Health Campus in 2016.

resultsMice immunized with USM.TOXO1 significantly induced a mixed Th1/Th2 response polarized toward the IgG1 antibody isotype. While the cytokine analysis revealed a significant release of IFN-γ cytokines.

conclusionUSM.TOXO1 is a potential vaccine candidate that elicits strong immunity in BALB/c mice. The proven immunogenicity of the generated antigen can serve as a premise for further use of epitope-based vaccine in the immunoprevention of human and animal toxoplasmosis.

Indexed as

GRA2GRA7Multiepitope peptideSAG1Toxoplasma gondiiVaccine

Identifiers

PMID30069205
PMCPMC6068360
OpenAlexW2886902689

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.