ArticleJournal of Korean medical science2018
A New Scoring System for the Differential Diagnosis between Tuberculous Meningitis and Viral Meningitis.
Article in Journal of Korean medical science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Systematic review of tuberculous meningitis in high-risk populations: mortality and diagnostic disparities.Future microbiologyPooled it
- Metagenomic next-generation sequencing of cerebrospinal fluid reveals pathogen spectrum and mortality predictors among patients with advanced HIV-1 disease at a tertiary hospital in China.Virology journal · 2026Article
- Incidence of cranial and ophthalmic nerve palsy and associated risk factors in tuberculous meningitis: A systematic review and meta-regression analysis.IBRO neuroscience reports · 2026Review
- Clinical scoring systems for diagnosing tuberculous meningitis: A systematic review.World journal of critical care medicine · 2026Article
- The Clinical Utility of Serum Biomarkers in the Differentiation and Prognostic Assessment of Viral Meningitis.Pathogens (Basel, Switzerland) · 2026Article
- Diagnosis of Tuberculous Meningitis: Integrating Clinical Assessment and Molecular Diagnostics.Diagnostics (Basel, Switzerland) · 2026Review
- Construction and verification of early diagnosis model of tuberculous meningitis.Frontiers in cellular and infection microbiology · 2026Article
- The progress of tuberculous meningitis medical management in adults.Surgical neurology international · 2026Review
- Article
- Concurrent Tuberculous Meningitis and Toxoplasma Encephalitis in an HIV-Positive Patient: An Exceptionally Rare Case.Cureus · 2025Article
- Tuberculous Meningitis Across the Lifespan.The Journal of infectious diseases · 2025Review
- A Rare Case of Wolfram Syndrome Presenting With Tuberculous Meningitis: A Case Report.Clinical case reports · 2025Article
- Diagnostic Challenges of Tuberculous Meningitis Initially Presenting as Otomastoiditis.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2025Article
- Pediatric Tuberculosis: A Review of Evidence-Based Best Practices for Clinicians and Health Care Providers.Pathogens (Basel, Switzerland) · 2024Review
- Article
- The effect of machine learning algorithms in the prediction, and diagnosis of meningitis: A systematic review.Health science reports · 2024Review
- Development and validation of a new model for the early diagnosis of tuberculous meningitis in adults based on simple clinical and laboratory parameters.BMC infectious diseases · 2023Article
- Development of clinical-based scoring system to diagnose tuberculous meningitis in children.Archives of disease in childhood · 2023Article
- Diagnostic challenges in tuberculous meningitis: a case report with negative genexpert result.Annals of medicine and surgery (2012) · 2023Article
- Tuberculostearic acid incorporated predictive model contributes to the clinical diagnosis of tuberculous meningitis.iScience · 2023Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTuberculous meningitis (TBM) is associated with high mortality and morbidity despite administering anti-tuberculous chemotherapy to the patients. Differential diagnosis between TBM and viral meningitis (VM) is difficult in some clinical situations.
methodsWe reviewed and analyzed records of adult patients who were admitted and diagnosed with TBM or VM at a tertiary hospital in Korea, between January 2006 and December 2015. Diagnostic criteria for TBM were categorized into three groups: definite, probable, and possible TBM. The VM group included patients with no evidence of other meningitis who achieved complete recovery with only conservative treatments. Clinical, laboratory and radiological findings, as well as outcomes, were compared between the TBM and VM groups.
resultsNinety-eight patients were enrolled. Among the study patients, 47 had TBM and 51 had VM. Based on univariate analysis and multivariate logistic regression, sodium < 135 mmol/L in serum (hyponatremia), lactate dehydrogenase > 70 (U/L) in cerebrospinal fluid (CSF), protein > 160 (mg/dL) in CSF, voiding difficulty, and symptoms of cranial nerve palsy were significant predictive factors for TBM in the final model. We constructed a weighted scoring system with predictive factors from multiple regression analyses. Receiver operating characteristic curve analyses and decision tree analyses were plotted to reveal an optimum cutoff point as 4 with this scoring system (range: 0-13).
conclusionFor differential diagnosis between TBM and VM, we created a new weighted scoring system. This scoring system and decision tree analysis are simple and easy to apply in clinical practice to differentiate TBM from VM.
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